Evidence map›Paper›PMID 32500526›Full record

GuidelineAllergy2020

Considerations on biologicals for patients with allergic disease in times of the COVID-19 pandemic: An EAACI statement.

Alessandra Vultaggio, Ioana Agache, Cezmi A Akdis, Mubeccel Akdis, Sevim Bavbek, Apostolos Bossios, Jean Bousquet, Onur Boyman, Adam M Chaker, Susan Chan and 15 more

Abstract readPractice Guideline
In one paragraph

Guideline in Allergy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Allergic diseases and immunodeficiencies in children, lessons learnt from COVID-19 pandemic by 2022: A statement from the EAACI-section on pediatrics.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Article
  8. Article
  9. COVID-19 and rhinological surgery.Operative techniques in otolaryngology--head and neck surgery · 2022
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Asthma and COVID-19: a dangerous liaison?Asthma research and practice · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Alessandra VultaggioImmunoallergology Unit, Careggi University Hospital, Florence, Italy.
Ioana AgacheTransylvania University, Brasov, Romania.ORCID 0000-0001-7994-364X
Cezmi A AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos, Switzerland.ORCID 0000-0001-8020-019X
Mubeccel AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos, Switzerland.ORCID 0000-0003-0554-9943
Sevim BavbekDepartment of Chest Disease, Division of Immunology and Allergy, School of Medicine, Ankara University, Ankara, Turkey.
Apostolos BossiosDepartment of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-0494-2690
Jean BousquetCharité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Onur BoymanDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0001-8279-5545
Adam M ChakerDepartment of Otolaryngology, TUM School of Medicine, Klinikumrechts der Isar, Center for Allergy and Environment, Technical University of Munich, Munich, Germany.
Susan ChanSchool of Immunology & Microbial Sciences, United Kingdom King's College London School of Life Course Sciences, King's Health Partners, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
Alexia ChatzipetrouAllergy Unit 2nd Department of Dermatology and Venereology, Medical School, National University of Athens, University General Hospital "ATTIKON", Athens, Greece.
Wojciech FeleszkoDepartment of Pediatric Allergy and Pneumology, Medical University of Warsaw, Warsaw, Poland.
Davide FirinuDepartment of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy.ORCID 0000-0002-5768-391X
Marek JutelDepartment of Clinical Immunology, Wroclaw Medical University, Wrocław, Poland.
Paula KauppiDepartment of Allergy, Inflammation Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland.
Ludger KlimekCentre for Rhinology and Allergy, Wiesbaden, Germany.
Antonios KoliosMACVIA-France, Montpellier, France.
Akash KothariTranslational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0003-1980-161X
Marek L KowalskiDepartment of Immunology and Allergy, Medical University of Lodz, Lodz, Poland.
Andrea MatucciImmunoallergology Unit, Careggi University Hospital, Florence, Italy.
Oscar PalomaresDepartment of Biochemistry and Molecular Biology, Chemistry School, Complutense University of Madrid, Madrid, Spain.ORCID 0000-0003-4516-0369
Oliver PfaarDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.ORCID 0000-0003-4374-9639
Barbara RogalaDepartment of Internal Diseases, Allergology & Clinical Immunology Medical, University of Silesia, Katowice, Poland.ORCID 0000-0002-3077-0271
Eva UntersmayrInstitute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1963-499X
Thomas EiweggerTranslational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-2914-7829

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The outbreak of the SARS-CoV-2-induced coronavirus disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant number of the patients are on treatment with biologicals, and clinicians face the challenge to provide optimal care during the pandemic. Uncertainty of the potential risks for these patients is related to the fact that the exact sequence of immunological events during SARS-CoV-2 is not known. Severe COVID-19 patients may experience a "cytokine storm" and associated organ damage characterized by an exaggerated release of pro-inflammatory type 1 and type 3 cytokines. These inflammatory responses are potentially counteracted by anti-inflammatory cytokines and type 2 responses. This expert-based EAACI statement aims to provide guidance on the application of biologicals targeting type 2 inflammation in patients with allergic disease. Currently, there is very little evidence for an enhanced risk of patients with allergic diseases to develop severe COVID-19. Studies focusing on severe allergic phenotypes are lacking. At present, noninfected patients on biologicals for the treatment of asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, or chronic spontaneous urticaria should continue their biologicals targeting type 2 inflammation via self-application. In case of an active SARS-CoV-2 infection, biological treatment needs to be stopped until clinical recovery and SARS-CoV-2 negativity is established and treatment with biologicals should be re-initiated. Maintenance of add-on therapy and a constant assessment of disease control, apart from acute management, are demanded.

Indexed as

Academies and InstitutesBiological ProductsCOVID-19EuropeHumansHypersensitivityPandemicsBiological Products

Identifiers

PMID32500526
PMCPMC7300800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.