Evidence map›Paper›PMID 32500443›Full record

ReviewCurrent rheumatology reports2020

An Update on the Diagnosis and Management of Lupus Nephritis.

Myrto Kostopoulou, Christina Adamichou, George Bertsias

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current rheumatology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06654024 (Assessment of Urinary Congophilia as an Indicator of Disease Activity of Lupus Nephritis), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06654024 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Assessment of Urinary Congophilia as an Indicator of Disease Activity of Lupus Nephritis

Typeobservational_patient_registrySponsorAssiut UniversityRan2024 to 2026Enrolled74ConditionsLupus Nephritis (LN)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

  1. Observational
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Myrto Kostopoulou4th Department of Internal Medicine, Attikon University Hospital, Joint Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Christina Adamichou4th Department of Internal Medicine, Hippokration University Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
George BertsiasDepartment of Rheumatology, Clinical Rheumatology and Allergy, University of Crete Medical School, 71008 Voutes-Stavrakia, Heraklion, Greece. gbertsias@uoc.gr.
Aristotle University of Thessaloniki · GRNational and Kapodistrian University of Athens · GRUniversity of Crete · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewUpdate on the diagnosis, treatment, and monitoring of lupus nephritis. RECENT

findingsThe recent criteria enable the earlier classification of lupus nephritis based on kidney biopsy and compatible serology. Treatment of active nephritis includes low-dose intravenous cyclophosphamide or mycophenolate, followed by maintenance immunosuppression. Recent trials have suggested superiority of regimens combining mycophenolate with either calcineurin inhibitor or belimumab, although their long-term benefit/risk ratio has not been determined. Encouraging results with novel anti-CD20 antibodies confirm the effectiveness of B cell depletion. Achievement of low-grade proteinuria (< 700-800 mg/24 h) at 12-month post-induction is linked to favorable long-term outcomes and could be considered in a treat-to-target strategy. Also, repeat kidney biopsy can guide the duration of maintenance immunosuppression. Lupus nephritis has increased cardiovascular disease burden necessitating risk-reduction strategies. An expanding spectrum of therapies coupled with ongoing basic/translational research can lead to individualized medical care and improved outcomes in lupus nephritis.

Indexed as

Lupus NephritisAntibodies, MonoclonalCalcineurin InhibitorsCyclophosphamideHumansImmunosuppressive AgentsMycophenolic AcidAntibodies, MonoclonalCalcineurin InhibitorsCyclophosphamideImmunosuppressive AgentsMycophenolic AcidBiologic agentsComorbiditiesFlaresRisk stratificationSystemic lupus erythematosusTherapeutic target

Identifiers

PMID32500443
OpenAlexW3033142911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.