Evidence map›Paper›PMID 32500285›Full record

ArticleDigestive diseases and sciences2020

Greater Peripouch Fat Area on CT Image Is Associated with Chronic Pouchitis and Pouch Failure in Inflammatory Bowel Diseases Patients.

Xian-Hua Gao, Guan-Yu Yu, Freeha Khan, Jin-Qiao Li, Luca Stocchi, Tracy L Hull, Bo Shen

Abstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Pouchitis: pathophysiology and management.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xian-Hua GaoDepartment of Colorectal Surgery, The Cleveland Clinic Foundation, Cleveland, OH, USA.
Guan-Yu YuDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, China.
Freeha KhanDepartment of Gastroenterology/Hepatology, The Cleveland Clinic Foundation, Cleveland, OH, USA.
Jin-Qiao LiDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, China.
Luca StocchiDepartment of Colorectal Surgery, The Cleveland Clinic Foundation, Cleveland, OH, USA.
Tracy L HullDepartment of Colorectal Surgery, The Cleveland Clinic Foundation, Cleveland, OH, USA.
Bo ShenDepartment of Gastroenterology/Hepatology, The Cleveland Clinic Foundation, Cleveland, OH, USA. bs3270@columbia.edu.ORCID 0000-0002-7229-4840
Cleveland Clinic · USSecond Military Medical University · CN

Funding

National Natural Science Foundation of China 81572332Shanghai Association for Science and Technology Shanghai Pujiang Program (#2019PJD052)
6 · The paper itself

Abstract

backgroundThe causes of chronic antibiotic refractory pouchitis (CARP) and pouch failure in inflammatory bowel disease (IBD) patients remain unknown. Our previous small study showed peripouch fat area measured by MRI was associated with pouchitis.

aimsTo explore the relationship between peripouch fat area on CT imaging and pouch outcomes.

methodsThis is a historical cohort study. Demographic, clinical, and radiographic data of IBD patients with abdominal CT scans after pouch surgery between 2002 and 2017 were collected. Peripouch fat areas and mesenteric peripouch fat areas were measured on CT images at the middle pouch level.

resultsA total of 435 IBD patients were included. Patients with higher peripouch fat areas had a higher prevalence of CARP. Univariate analyses demonstrated that long duration of the pouch, high weight or body mass index, the presence of primary sclerosing cholangitis or other autoimmune disorders, and greater peripouch fat area or mesenteric peripouch fat area were risk factors for CARP. Multivariable analyses demonstrated that the presence of primary sclerosing cholangitis or autoimmuned disorders, and greater peripouch fat area (odds ratio [OR] 1.031; 95% confidence interval [CI] 1.016-1.047, P < 0.001) or mesenteric peripouch fat area were independent risk factors for CARP. Of the 435 patients, 139 (32.0%) had two or more CT scans. Multivariable Cox proportional hazard analyses showed that "peripouch fat area increase ≥ 15%" (OR 3.808, 95%CI 1.703-8.517, P = 0.001) was an independent predictor of pouch failure.

conclusionsA great peripouch fat area measured on CT image is associated with a higher prevalence of CARP, and the accumulation of peripouch fat is a risk factor for pouch failure. The assessment of peripouch fat may be used to monitor the disease course of the ileal pouch.

Indexed as

Colonic PouchesInflammatory Bowel DiseasesIntra-Abdominal FatMesenteryPouchitisAutoimmune DiseasesChinaCohort StudiesDrug Resistance, BacterialFemaleHumansMaleMiddle AgedOverweightProctocolectomy, RestorativeRisk FactorsChronic antibiotic refractory pouchitis (CARP)Ileal pouch anal anastomosis (IPAA)Inflammatory bowel diseasePeripouch fatPouch failure

Identifiers

PMID32500285
OpenAlexW3033401718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.