Evidence map›Paper›PMID 32500249›Full record

ReviewPediatric nephrology (Berlin, Germany)2021

Childhood risk factors for adulthood chronic kidney disease.

Michal Stern-Zimmer, Ronit Calderon-Margalit, Karl Skorecki, Asaf Vivante

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Article
  5. Observational
  6. Observational
  7. Article
  8. Detect early, protect kidney health: World Kidney Day 2025.Pediatric nephrology (Berlin, Germany) · 2025
    Article
  9. Chronic kidney disease.Nature reviews. Disease primers · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Childhood Obesity: Insight into Kidney Involvement.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Michal Stern-ZimmerPediatric Department B and Pediatric Nephrology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel, Tel-Aviv University, Tel-Aviv, Israel.
Ronit Calderon-MargalitHadassah-Hebrew University Braun School of Public Health, Jerusalem, Israel.
Karl SkoreckiAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Asaf VivantePediatric Department B and Pediatric Nephrology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel, Tel-Aviv University, Tel-Aviv, Israel. asafvivante@gmail.com.
Bar-Ilan University · ILEdmond and Lily Safra Children's Hospital · ILHebrew University of Jerusalem · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is a major public health challenge, affecting as much as 8 to 18% of the world population. Identifying childhood risk factors for future CKD may help clinicians make early diagnoses and initiation of preventive interventions for CKD and its attendant comorbidities as well as monitoring for complications. The purpose of this review is to describe childhood risk factors that may predict development of overt kidney disease later in life. Currently, there are multiple childhood risk factors associated with future onset and progression of CKD. These risk factors can be grouped into five categories: genetic factors (e.g., monogenic or risk alleles), perinatal factors (e.g., low birth weight and prematurity), childhood kidney diseases (e.g., congenital anomalies, glomerular diseases, and renal cystic ciliopathies), childhood onset of chronic conditions (e.g., cancer, diabetes, hypertension, dyslipidemia, and obesity), and different lifestyle factors (e.g., physical activity, diet, and factors related to socioeconomic status). The available published information suggests that the lifelong risk for CKD can be attributed to multiple factors that appear already during childhood. However, results are conflicting on the effects of childhood physical activity, diet, and dyslipidemia on future renal function. On the other hand, there is consistent evidence to support follow-up of high-risk groups.

Indexed as

Renal Insufficiency, ChronicAdultChildDisease ProgressionHumansInfant, Low Birth WeightInfant, NewbornRisk FactorsSocial ClassChronic kidney diseaseEnd stage kidney disease

Identifiers

PMID32500249
OpenAlexW3034166768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.