ArticlePediatric nephrology (Berlin, Germany)2020
Follow-up after neonatal heart disease repair: watch out for chronic kidney disease and hypertension!
Article in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Chronic kidney disease following pediatric cardiac surgery: a systematic review and meta-analysis.BMC pediatrics · 2026Pooled it
- Risk factors and mortality of postoperative acute kidney injury (AKI) in newborns across geographical regions, surgical type, and national economic levels: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Neonatal acute kidney injury: Reassessing diagnostic criteria for acute kidney injury in neonates with hypoxic-ischaemic encephalopathy undergoing therapeutic hypothermia.Pediatric nephrology (Berlin, Germany) · 2026Article
- Exploring Racial and Ethnic Disparities in Outcomes Following Pediatric Cardiac Surgery: A NEPHRON Study Analysis.Pediatric cardiology · 2026Article
- Urine Output Response to a Furosemide Infusion in Infants After Cardiopulmonary Bypass as a Predictor of Acute Kidney Injury.Pediatric cardiology · 2026Article
- Impact of acute kidney injury and dysnatremia on length of stay in infants after cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2025Article
- Cardiac surgery-associated acute kidney injury in neonatal Norwood procedure: incidence, risk factors and impact on mortality and outcomes.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Kidney and blood pressure outcomes 11 years after pediatric critical illness and longitudinal impact of AKI: a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Framework for Kidney Health Follow-Up Among Neonates With Critical Cardiac Disease: A Report From the Neonatal Kidney Health Consensus Workshop.Journal of the American Heart Association · 2025Review
- Pediatric acute kidney injury and adverse health outcomes: using a foundational framework to evaluate a causal link.Pediatric nephrology (Berlin, Germany) · 2024Review
- Advocating for the inclusion of kidney health outcomes in neonatal research: best practice recommendations by the Neonatal Kidney Collaborative.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Kidney Health Monitoring in Neonatal Intensive Care Unit Graduates: A Modified Delphi Consensus Statement.JAMA network open · 2024Article
- Kidney and urological involvement in Down syndrome: frequent, underestimated, but associated with impaired quality of life and risk of kidney failure.Pediatric nephrology (Berlin, Germany) · 2024Review
- Kidney outcomes in early adolescence following perinatal asphyxia and hypothermia-treated hypoxic-ischaemic encephalopathy.Pediatric nephrology (Berlin, Germany) · 2023Article
- Persistent Markers of Kidney Injury in Children Who Developed Acute Kidney Injury After Pediatric Cardiac Surgery: A Prospective Cohort Study.Journal of the American Heart Association · 2022Article
- Reference serum creatinine levels according to sex, age, and height in children with Down syndrome.European journal of pediatrics · 2021Article
- Article
- Long-term Risk of Hypertension After Surgical Repair of Congenital Heart Disease in Children.JAMA network open · 2021Article
- Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years.Frontiers in pediatrics · 2021Review
- Continuous Renal Replacement Therapy in Critically Ill Children in the Pediatric Intensive Care Unit: A Retrospective Analysis of Real-Life Prescriptions, Complications, and Outcomes.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundWith advances in care, neonates undergoing cardiac repairs are surviving more frequently. Our objectives were to 1) estimate the prevalence of chronic kidney disease (CKD) and hypertension 6 years after neonatal congenital heart surgery and 2) determine if cardiac surgery-associated acute kidney injury (CS-AKI) is associated with these outcomes.
methodsTwo-center prospective, longitudinal single-visit cohort study including children with congenital heart disease surgery as neonates between January 2005 and December 2012. CKD (estimated glomerular filtration rate < 90 mL/min/1.73m
resultsFifty-eight children with median follow-up of 6 years were evaluated. CS-AKI occurred in 58%. CKD and hypertension prevalence were 17% and 30%, respectively; an additional 15% were classified as having elevated blood pressure. CS-AKI was not associated with CKD or hypertension. Classification as cyanotic postoperatively was the only independent predictor of CKD. Postoperative days in hospital predicted hypertension at follow-up.
conclusionsThe prevalence of CKD and hypertension is high in children having neonatal congenital heart surgery. This is important; early identification of CKD and hypertension can improve outcomes. These children should be systematically followed for the evolution of these negative outcomes. CS-AKI defined by current standards may not be a useful clinical tool to decide who needs follow-up and who does not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.