Evidence map›Paper›PMID 32500239›Full record

ArticleInternational journal of public health2020

Epidemiology and clinical course of primary biliary cholangitis in Eastern Slovakia.

Sylvia Drazilova, Ingrid Babinska, Jakub Gazda, Monika Halanova, Martin Janicko, Branislav Kucinsky, Dominik Safcak, Dominika Martinkova, Lucia Tarbajova, Anna Cekanova and 2 more

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In one paragraph

Article in International journal of public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. The treatment of primary biliary cholangitis: from shadow to light.Therapeutic advances in gastroenterology · 2024
    Review
  7. Risk Stratification in Primary Biliary Cholangitis.Journal of clinical medicine · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sylvia DrazilovaDepartment of Internal Medicine, Hospital Poprad, Poprad, Slovakia.ORCID http://orcid.org/0000-0003-2448-6757
Ingrid BabinskaDepartment of Epidemiology, PJ Safarik University, Faculty of Medicine, Kosice, Slovakia. ingrid.babinska@upjs.sk.ORCID http://orcid.org/0000-0002-3586-1180
Jakub Gazda2nd Department of Internal Medicine, Faculty of Medicine and L Pasteur University Hospital, PJ Safarik University, Kosice, Slovakia.ORCID http://orcid.org/0000-0003-2246-2217
Monika HalanovaDepartment of Epidemiology, PJ Safarik University, Faculty of Medicine, Kosice, Slovakia.
Martin Janicko2nd Department of Internal Medicine, Faculty of Medicine and L Pasteur University Hospital, PJ Safarik University, Kosice, Slovakia.ORCID http://orcid.org/0000-0002-3329-3968
Branislav Kucinsky2nd Department of Internal Medicine, Faculty of Medicine and L Pasteur University Hospital, PJ Safarik University, Kosice, Slovakia.
Dominik Safcak2nd Department of Internal Medicine, Faculty of Medicine and L Pasteur University Hospital, PJ Safarik University, Kosice, Slovakia.
Dominika MartinkovaDepartment of Internal Medicine, Hospital Poprad, Poprad, Slovakia.
Lucia TarbajovaDepartment of Internal Medicine, Hospital Poprad, Poprad, Slovakia.
Anna Cekanova2nd Department of Internal Medicine, Faculty of Medicine and L Pasteur University Hospital, PJ Safarik University, Kosice, Slovakia.
Peter Jarcuska2nd Department of Internal Medicine, Faculty of Medicine and L Pasteur University Hospital, PJ Safarik University, Kosice, Slovakia.ORCID http://orcid.org/0000-0001-6169-9984
Eastern Slovakia PBC Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine both the incidence and the prevalence of primary biliary cholangitis (PBC) in Eastern Slovakia and to describe its clinical course and the response to ursodeoxycholic acid (UDCA).

methodsWe recorded data of patients with PBC, who were followed up in gastroenterology and hepatology centers in Eastern Slovakia during the period from June 30, 1999, through June 30, 2019.

resultsThe annual incidence of PBC varied from 0.7 to 1.5 cases per 100,000 inhabitants between 2014 and 2018. PBC prevalence steadily increased from initial 10.2 cases per 100,000 inhabitants in 2014 to 14.9 cases per 100,000 inhabitants in June 2019. The mean age at the time of diagnosis was 56.3 ± 10.9 years. 95.7% of patients were females, and female/male gender ratio was 22.3:1. In June 2019, prevalence in the female population was 28 cases per 100,000 women. At the time of diagnosis, three-quarters of patients were symptomatic and 10% of patients had liver cirrhosis. The mean follow-up was 7.3 ± 5.2 years. Response to UDCA was observed in 72.1% of patients. Patients with higher baseline alkaline phosphatase (ALP) levels, liver cirrhosis at entry or at the end of follow-up and women younger than 45 years responded worse to UDCA. One-quarter of patients had liver cirrhosis at the end of follow-up. During follow-up, 1.6% of patients underwent liver transplantation and 5.5% of patients died. Five-year and 10-year liver-related mortalities were 2.7% and 4.3%, respectively.

conclusionPBC prevalence in Eastern Slovakia is increasing, and most of the patients respond to therapy with UDCA.

Indexed as

AgedCholagogues and CholereticsFemaleHumansIncidenceLiver Cirrhosis, BiliaryMaleMiddle AgedPrevalenceSlovakiaUrsodeoxycholic AcidCholagogues and CholereticsUrsodeoxycholic AcidClinical courseIncidencePrevalencePrimary biliary cholangitisUrsodeoxycholic acid

Identifiers

PMID32500239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.