Evidence map›Paper›PMID 32500186›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2020

The expression levels of CHI3L1 and IL15Rα correlate with TGM2 in duodenum biopsies of patients with celiac disease.

Paola Catrogiovanni, Giuseppe Musumeci, Salvatore Giunta, Rosa Imbesi, Michelino Di Rosa

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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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  8. BrainCells · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Paola CatrogiovanniAnatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 87, 95125, Catania, Italy.
Giuseppe MusumeciAnatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 87, 95125, Catania, Italy.
Salvatore GiuntaAnatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 87, 95125, Catania, Italy.
Rosa ImbesiAnatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 87, 95125, Catania, Italy.
Michelino Di RosaAnatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 87, 95125, Catania, Italy. chitotriosidase@gmail.com.ORCID http://orcid.org/0000-0002-1837-9325
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OBJECTIVE AND

designCeliac disease (CD) is an intestinal inflammatory disorder of the small intestine. Gliadins are a component of gluten and there are three main types (α, γ, and ω). Recent studies indicate that gliadin peptides are able to activate an innate immune response. IL15 is a major mediator of the innate immune response and is involved in the early alteration of CD mucosa. The chitinase molecules are highly expressed by the innate immune cells during the inflammatory processes. MATERIAL OR SUBJECTS: We analyzed several microarray datasets of PBMCs and duodenum biopsies of CD patients and healthy control subjects (HCs). We verified the modulation CHI3L1 in CD patients and correlated the expression levels to the IL15, IL15Rα, TGM2, IFNγ, and IFNGR1/2. Duodenal biopsy samples belonged to nine active and nine treated children patients (long-term effects of gliadin), and 17 adult CD patients and 10 adults HCs. We also selected 169 samples of PBMCs from 127 CD patients on adherence to a gluten-free diet (GFD) for at least 2 years and 44 HCs.

resultsOur analysis showed that CHI3L1 and IL15Rα were significantly upregulated in adult and children's celiac duodenum biopsies. In addition, the two genes were correlated significantly both in children than in adults CD duodenum biopsies. No significant modulation was observed in PBMCs of adult CD patients compared to the HCs. The correlation analysis of the expression levels of CHI3L1 and IL15Rα compared to TGM showed significant values both in adults and in children duodenal biopsies. Furthermore, the IFNγ expression levels were positively correlated with CHI3L1 and IL15Rα. Receiver operating characteristic (ROC) analysis confirmed the diagnostic ability of CHI3L1 and IL15Rα to discriminate CD from HCs.

conclusionOur data suggest a role for CHI3L1 underlying the pathophysiology of CD and represent a starting point aiming to inspire new investigation that proves the possible use of CHI3L1 as a diagnostic factor and therapeutic target.

Indexed as

AdultBiopsyCeliac DiseaseChildChitinase-3-Like Protein 1DuodenumGTP-Binding ProteinsHumansInterleukin-15 Receptor alpha SubunitProtein Glutamine gamma Glutamyltransferase 2TransglutaminasesCHI3L1 protein, humanChitinase-3-Like Protein 1GTP-Binding ProteinsInterleukin-15 Receptor alpha SubunitProtein Glutamine gamma Glutamyltransferase 2TGM2 protein, humanTransglutaminasesBioinformaticsCeliac diseaseCHI3L1ChitinasesIL15IL15Rα

Identifiers

PMID32500186
OpenAlexW3033295202

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.