Evidence map›Paper›PMID 32500175›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021

CZT camera systems may provide better risk stratification for low-risk patients.

Robert J H Miller, Donghee Han, Alan Rozanski, Heidi Gransar, John D Friedman, Sean Hayes, Louise Thomson, Balaji Tamarappoo, Piotr J Slomka, Daniel S Berman

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Advanced technology in the risk stratification-based strategy: The way forward to keep going.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Robert J H MillerDepartments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Donghee HanDepartments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Alan RozanskiDivision of Cardiology, Mount Sinai St. Luke's Hospital, Mount Sinai Heart, and the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Heidi GransarDepartments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
John D FriedmanDepartments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Sean HayesDepartments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Louise ThomsonDepartments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Balaji TamarappooDepartments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Piotr J SlomkaDepartments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Daniel S BermanDepartments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. bermand@cshs.org.
Cedars-Sinai Medical Center · USSt. Luke's Hospital · USUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe photon sensitivity and spatial resolution of single-photon emission-computed tomography (SPECT) has been significantly improved by solid-state camera systems using cadmium zinc telluride (CZT) detectors. While the diagnostic accuracy of these systems is well established, there is little evidence directly comparing the prognostic utility to conventional NaI cameras. METHODS AND

resultsRetrospective analysis of patients undergoing SPECT between 2008 and 2012. Visual SPECT assessment was performed utilizing the 17-segment model to determine summed stress scores (SSS). We identified 12,830 consecutive patients, mean age 63.2 ± 13.7 and 56.1% male, 5072 of whom underwent CZT and 7758 NaI imaging. During a median follow-up duration of 7.0 years (IQR 5.5-8.2), a total of 2788 (21.7%) patients died. Compared to SSS 0, minimal perfusion abnormality (SSS 1-3) was associated with increased all-cause mortality with CZT camera (adjusted HR 1.32, P = .017) and NaI camera (adjusted HR 1.29, P = .001, interaction P = .803). Increasing stress abnormality was associated with a similar increase in risk with CZT or NaI imaging (interaction P > .500). In a propensity matched analysis, patients with normal perfusion stress perfusion assessed with a CZT was associated with decreased mortality compared to normal perfusion assessed by a NaI camera system (hazard ratio .88, 95% CI .78-.99, P = .040).

conclusionsIncreasing stress perfusion abnormality was associated with similar increase in all-cause mortality with CZT or NaI cameras. CZT and NaI camera systems provide similar risk stratification, however, normal myocardial perfusion may be associated with a more benign prognosis when assessed with a CZT camera system.

Indexed as

CadmiumTelluriumZincAgedFemaleGamma CamerasHumansMaleMiddle AgedMyocardial Perfusion ImagingRetrospective StudiesRisk AssessmentCadmiumCdZnTeTelluriumZincCZTmyocardial perfusion imagingSPECT

Identifiers

PMID32500175
OpenAlexW3033153323

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.