ArticleBiomedical optics express2020
Non-invasive investigation of adipose tissue by time domain diffuse optical spectroscopy.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Breath-by-breath lung gas volume detection using GASMAS in a neonatal mannequin.Pediatric research · 2026Article
- Abdominal Adipose Tissue Fibrosis as an Obesity Biomarker in Clinical Practice.Obesity facts · 2026Article
- In-vivo optical properties spectra across five body locations on ten subjects using time-domain diffuse optics.Scientific data · 2026Article
- Noninvasive prediction of photon fluence rate in targeted brain regions for personalized transcranial photobiomodulation dosage: model development andBiomedical optics express · 2025Article
- Influence of Uncertainties in Optode Positions on Self-Calibrating or Dual-Slope Diffuse Optical Measurements.Photonics · 2025Article
- Finite Element Modeling of Abdominal Near-Infrared Spectroscopy for Infant Splanchnic Oximetry.International journal for numerical methods in biomedical engineering · 2025Article
- Near-Infrared Spectroscopic Mapping of the Human Epicardium.Journal of biophotonics · 2025Article
- Measurement of tissue optical properties in the 400 to 700 nm range to assess light penetration depths for laser treatment of upper tract urothelial carcinomas.Journal of biomedical optics · 2024Article
- Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies.Biomedical optics express · 2024Article
- Interstitial null-distance time-domain diffuse optical spectroscopy using a superconducting nanowire detector.Journal of biomedical optics · 2023Article
- Recovering fetal signals transabdominally through interferometric near-infrared spectroscopy (iNIRS).Biomedical optics express · 2023Article
- Solid optical tissue phantom tools based on upconverting nanoparticles for biomedical applications.Journal of biomedical optics · 2023Article
- VIS-NIR Diffuse Reflectance Spectroscopy System with Self-Calibrating Fiber-Optic Probe: Study of Perturbation Resistance.Diagnostics (Basel, Switzerland) · 2023Article
- Measurement of tissue optical properties in a wide spectral range: a review [Invited].Biomedical optics express · 2023Review
- Optical Characterization of Biological Tissues Based on Fluorescence, Absorption, and Scattering Properties.Diagnostics (Basel, Switzerland) · 2022Article
- Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise.Journal of biomedical optics · 2022Article
- Intraoperative colon perfusion assessment using multispectral imaging.Biomedical optics express · 2021Article
- Broadband absorption spectroscopy of heterogeneous biological tissue.Applied optics · 2021Article
- Narrowband diffuse reflectance spectroscopy in the 900-1000 nm wavelength region to quantify water and lipid content of turbid media.Biomedical optics express · 2021Article
- Dual-Slope Diffuse Reflectance Instrument for Calibration-Free Broadband Spectroscopy.Applied sciences (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human abdominal region is very heterogeneous and stratified with subcutaneous adipose tissue (SAT) being one of the primary layers. Monitoring this tissue is crucial for diagnostic purposes and to estimate the effects of interventions like caloric restriction or bariatric surgery. However, the layered nature of the abdomen poses a major problem in monitoring the SAT in a non-invasive way by diffuse optics. In this work, we examine the possibility of using multi-distance broadband time domain diffuse optical spectroscopy to assess the human abdomen non-invasively. Broadband absorption and reduced scattering spectra from 600 to 1100 nm were acquired at 1, 2 and 3 cm source-detector distances on ten healthy adult male volunteers, and then analyzed using a homogeneous model as an initial step to understand the origin of the detected signal and how tissue should be modeled to derive quantitative information. The results exhibit a clear influence of the layered nature on the estimated optical properties. Clearly, the underlying muscle makes a relevant contribution in the spectra measured at the largest source-detector distance for thinner subjects related to blood and water absorption. More unexpectedly, also the thin superficial skin layer yields a direct contamination, leading to higher water content and steeper reduced scattering spectra at the shortest distance, as confirmed also by simulations. In conclusion, provided that data analysis properly accounts for the complex tissue structure, diffuse optics may offer great potential for the continuous non-invasive monitoring of abdominal fat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.