Evidence map›Paper›PMID 32499959›Full record

ArticleBiomedical optics express2020

Imaging intracellular motion with dynamic micro-optical coherence tomography.

Hui Min Leung, Michelle L Wang, Hany Osman, Elham Abouei, Calum MacAulay, Michele Follen, Joseph A Gardecki, Guillermo J Tearney

Abstract read
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
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  9. Label-free viability assessment ofBiomedical optics express · 2026
    Article
  10. Review
  11. Article
  12. Guide to dynamic OCT data analysis.Biomedical optics express · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Article
  19. The State of High-Resolution Imaging of the Human Inner Ear: A Look Into the Black Box.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hui Min LeungWellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Michelle L WangWellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Hany OsmanWellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Elham AboueiUniversity of British Columbia, Department of Physics and Astronomy, Vancouver, BC V6 T 1Z1, Canada.
Calum MacAulayBritish Columbia Cancer Research Center, Department of Integrative Oncology, Vancouver, BC V5Z 1L3, Canada.
Michele FollenNYC Health + Hospitals/Kings County, Cancer Prevention and Cancer Services for Kings County Hospital, 451 Clarkson Avenue, C-Building, Suite 4104, Brooklyn, NY 11203, USA.
Joseph A GardeckiWellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Guillermo J TearneyWellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Funding

MGHfC Digestive Disease Summer Research ProgramR25DK103579 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BRYAN P HURLEY · 2015 to 2026
$1.2M
6 · The paper itself

Abstract

This paper describes a new technology that uses 1-µm-resolution optical coherence tomography (µOCT) to obtain cross-sectional images of intracellular dynamics with dramatically enhanced image contrast. This so-called dynamic µOCT (d-µOCT) is accomplished by acquiring a time series of µOCT images and conducting power frequency analysis of the temporal fluctuations that arise from intracellular motion on a pixel-per-pixel basis. Here, we demonstrate d-µOCT imaging of freshly excised human esophageal and cervical biopsy samples. Depth-resolved d-µOCT images of intact tissue show that intracellular dynamics provides a new contrast mechanism for µOCT that highlights subcellular morphology and activity in epithelial surface maturation patterns.

Identifiers

PMID32499959
PMCPMC7249806

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.