ArticleBiomedical optics express2020
Characterization of early-stage cutaneous radiation injury by using optical coherence tomography angiography.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- [ROMO1 Promotes the Repair of Radiation-induced Skin Injury by Regulating Mitochondrial Function and Keratinocyte Proliferation].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- Feature-Based vs. Deep-Learning Fusion Methods for the In Vivo Detection of Radiation Dermatitis Using Optical Coherence Tomography, a Feasibility Study.Journal of imaging informatics in medicine · 2025Article
- Development and performance validation of an affordable and portable high-resolution darkfield polarization-sensitive multispectral imaging microscope for the assessment of radiation dermatitis and fibrosis.Biomedical optics express · 2025Article
- Cutaneous and local radiation injuries.Journal of radiological protection : official journal of the Society for Radiological Protection · 2022Review
- Deep-learning approach for automated thickness measurement of epithelial tissue and scab using optical coherence tomography.Journal of biomedical optics · 2022Article
- Acute Radiation Dermatitis Evaluation with Reflectance Confocal Microscopy: A Prospective Study.Diagnostics (Basel, Switzerland) · 2021Article
- Effect of A-scan rate and interscan interval on optical coherence angiography.Biomedical optics express · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cutaneous radiation injury (CRI) is a skin injury caused by exposure to high dose ionizing radiation (IR). Diagnosis and treatment of CRI is difficult due to its initial clinically latent period and the following inflammatory bursts. Early detection of CRI before clinical symptoms will be helpful for effective treatment, and various optical methods have been applied with limitations. Here we show that optical coherence tomography angiography (OCTA) could detect changes in the skin during the latent period in CRI mouse models non-invasively. CRI was induced on the mouse hindlimb with exposure to various IR doses and the injured skin regions were imaged longitudinally by OCTA until the onset of clinical symptoms. OCTA detected several changes in the skin including the skin thickening, the dilation of large blood vessels, and the irregularity in vessel boundaries. Some of OCTA findings were confirmed by histology. The study results showed that OCTA could be used for early CRI detection.
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Registered trials
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