ArticleJornal vascular brasileiro2020
Acute aortic wall injury caused by aortic cross-clamping: morphological and biomechanical study of the aorta in a swine model of three aortic surgery approaches.
Article in Jornal vascular brasileiro, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Diabetes Mellitus and Cardiopulmonary Bypass (CPB): Pathophysiological Mechanisms Related to Inflammation and Cardiovascular Disease.Current issues in molecular biology · 2025Review
- Aortic ischemia-reperfusion injury and potency of fluoxetine.Iranian journal of basic medical sciences · 2023Article
- Comparative angiotomographic study of swine vascular anatomy: contributions to research and training models in vascular and endovascular surgery.Jornal vascular brasileiro · 2021Article
- Biomechanical and morphological evaluation of aortic wall changes related to the cross-clamping method in different surgical techniques.Jornal vascular brasileiro · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
backgroundAortic cross-clamping and balloon occlusion of the aorta could lead to damage to the aorta wall.
objectiveThe aim of this study was to investigate changes to the aorta wall related to the method used to interrupt flow (clamping or balloon) in the different techniques available for aortic surgery.
methodsExperiments were performed on 40 female pigs, weighing 25-30kg, which were randomly allocated to 4 study groups: S (n=10), no intervention (sham group); C (n=10), midline transperitoneal laparotomy for infrarenal abdominal aortic access with 60 min of cross-clamping; L (n=10), laparoscopic infrarenal abdominal aortic surgery with 60 min of cross-clamping; EV (n=10), remote proximal aortic control with transfemoral arterial insertion of aortic occlusion balloon catheter, inflated to provide continued aortic occlusion for 60min. After euthanasia, the aortas were removed and cross-sectioned to obtain histological specimens for light microscopic and morphometric analyses. The remaining longitudinal segments were stretched to rupture and mechanical parameters were determined.
resultsWe observed a reduction in the yield point of the abdominal aorta, decrease in stiffness and in failure load in the aortic cross-clamping groups (C and L) compared with the EV group.
conclusionsAortic cross-clamping during open or laparoscopic surgery can affect the mechanical properties of the aorta leading to decrease in resistance of the aorta wall, without structural changes in aorta wall histology.
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