Evidence map›Paper›PMID 32499818›Full record

ArticleFrontiers in genetics2020

CircRNA_103809 Suppresses the Proliferation and Metastasis of Breast Cancer Cells by Sponging MicroRNA-532-3p (miR-532-3p).

Minfeng Liu, Can Luo, Jianyu Dong, Jingyun Guo, Qing Luo, Changsheng Ye, Zhaoze Guo

Abstract read
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Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
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  7. Article
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  9. Review
  10. circRNAs and their relationship with breast cancer: a review.World journal of surgical oncology · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Minor and major circRNAs in virus and host genomes.Journal of microbiology (Seoul, Korea) · 2021
    Review
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  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Minfeng LiuDepartment of Breast, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Can LuoDepartment of Breast, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jianyu DongDepartment of Breast, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jingyun GuoDepartment of Breast, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Qing LuoDepartment of Breast, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Changsheng YeDepartment of Breast, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhaoze GuoDepartment of Breast, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer has become one of the most serious disease threatening mankind health in the world. Accumulating studies indicated that circRNAs played an important role in the occurrence and progression of breast cancer, however, the roles of circRNA_103809 in breast cancer progression remain unclear. Therefore, in this study, we aimed to clarify the potential role and regulatory mechanism of circRNA_103809 in the development of breast cancer. Firstly, the expression level of circRNA_103809 and microRNA-532-3p (miR-532-3p) in breast cancer tissues and normal tissues were detected with the quantitative real-time polymerase chain reaction (RT-qPCR). In addition, the cell proliferation ability, metastasis ability and related pathways were identified by Cell Counting Kit-8 (CCK-8), flow cytometry, and western blot, respectively. Furthermore, the connection between circRNA_103809 and miR-532-3p was detected by dual-luciferase reporter assay. Then, our data showed that circRNA_103809 was down-regulated in breast cancer tissues in contrast to adjacent non-tumor tissues, and the relative expression level of circRNA_103809 was closely associated with distant metastasis size, TNM stage, HER-2 status and overall survival time. In addition, our

Indexed as

breast cancercircRNA_103809metastasismiR-532-3pproliferation

Identifiers

PMID32499818
PMCPMC7243809

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.