Evidence map›Paper›PMID 32499756›Full record

ReviewFrontiers in endocrinology2020

The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging.

Saad Khan, Yi Tao Chan, Xavier S Revelo, Daniel A Winer

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Saad KhanDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Yi Tao ChanDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Xavier S ReveloCenter for Immunology, University of Minnesota, Minneapolis, MN, United States.
Daniel A WinerDepartment of Immunology, University of Toronto, Toronto, ON, Canada.

Funding

Mechanisms of B Cell Pathogenicity in Non-Alcoholic Fatty Liver DiseaseR01DK122056 · NIDDK · UNIVERSITY OF MINNESOTA · PI REVELO, XAVIER · 2019 to 2023
$1.7M
CIHR FDN-148385NIDDK NIH HHS R01 DK122056
6 · The paper itself

Abstract

Obesity and aging represent major health burdens to the global adult population. Both conditions promote the development of associated metabolic diseases such as insulin resistance. The visceral adipose tissue (VAT) is a site that becomes dysfunctional during obesity and aging, and plays a significant role during their pathophysiology. The changes in obese and aging VAT are now recognized to be partly driven by a chronic local inflammatory state, characterized by immune cells that typically adopt an inflammatory phenotype during metabolic disease. Here, we summarize the current knowledge on the immune cell landscape of the VAT during lean, obese, and aged conditions, highlighting their similarities and differences. We also briefly discuss possible linked mechanisms that fuel obesity- and age-associated VAT dysfunction.

Indexed as

AgingAnimalsHumansIntra-Abdominal FatObesityagingdiabetesimmunologyimmunometabolisminsulin resistancemetabolismobesityvisceral adipose tissue

Identifiers

PMID32499756
PMCPMC7243349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.