ArticleHeredity2020
Evolution of novel genes in three-spined stickleback populations.
Article in Heredity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- DetectNAR genomics and bioinformatics · 2026Article
- Emergence and evolution of protein-coding de novo genes.Nature reviews. Genetics · 2026Review
- Impact of GC content on de novo gene birth.Nature communications · 2026Article
- Article
- Expression of De Novo Open Reading Frames in Natural Populations of Drosophila melanogaster.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Expression analyses of chemosensory genes provide insights into evolution of gustatory receptor genes in the bumble bee Bombus impatiens.BMC genomics · 2025Article
- The role of heterochronic gene expression and regulatory architecture in early developmental divergence.eLife · 2024Article
- High Polymorphism Levels of De Novo ORFs in a Yoruba Human Population.Genome biology and evolution · 2024Article
- DNA Transposons Favor De Novo Transcript Emergence Through Enrichment of Transcription Factor Binding Motifs.Genome biology and evolution · 2024Article
- High-throughput Selection of Human de novo-emerged sORFs with High Folding Potential.Genome biology and evolution · 2024Article
- Overlaps Between CDS Regions of Protein-Coding Genes in the Human Genome: A Case Study on the NR1D1-THRA Gene Pair.Journal of molecular evolution · 2023Article
- Towards understanding paleoclimate impacts on primate de novo genes.G3 (Bethesda, Md.) · 2023Article
- Orphan gene expressed in flame cone cells uniquely found in seahorse epithelium.Cell and tissue research · 2023Article
- Population genomics reveals mechanisms and dynamics of de novo expressed open reading frame emergence inGenome research · 2023Article
- De novo birth of functional microproteins in the human lineage.Cell reports · 2022Article
- Article
- Diversity in Expression Biases of Lineage-Specific Genes During Development and Anhydrobiosis Among Tardigrade Species.Evolutionary bioinformatics online · 2022Article
- Article
- Evolutionary divergence of novel open reading frames in cichlids speciation.Scientific reports · 2020Article
- Stochastic Gain and Loss of Novel Transcribed Open Reading Frames in the Human Lineage.Genome biology and evolution · 2020Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic genomes frequently acquire new protein-coding genes which may significantly impact an organism's fitness. Novel genes can be created, for example, by duplication of large genomic regions or de novo, from previously non-coding DNA. Either way, creation of a novel transcript is an essential early step during novel gene emergence. Most studies on the gain-and-loss dynamics of novel genes so far have compared genomes between species, constraining analyses to genes that have remained fixed over long time scales. However, the importance of novel genes for rapid adaptation among populations has recently been shown. Therefore, since little is known about the evolutionary dynamics of transcripts across natural populations, we here study transcriptomes from several tissues and nine geographically distinct populations of an ecological model species, the three-spined stickleback. Our findings suggest that novel genes typically start out as transcripts with low expression and high tissue specificity. Early expression regulation appears to be mediated by gene-body methylation. Although most new and narrowly expressed genes are rapidly lost, those that survive and subsequently spread through populations tend to gain broader and higher expression levels. The properties of the encoded proteins, such as disorder and aggregation propensity, hardly change. Correspondingly, young novel genes are not preferentially under positive selection but older novel genes more often overlap with F
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