Evidence map›Paper›PMID 32499657›Full record

ArticleNature2020

poly(UG)-tailed RNAs in genome protection and epigenetic inheritance.

Aditi Shukla, Jenny Yan, Daniel J Pagano, Anne E Dodson, Yuhan Fei, Josh Gorham, J G Seidman, Marvin Wickens, Scott Kennedy

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 155 citations in OpenAlex.

  1. Article
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  8. TDP-43 controls RNA structure through high affinity lattice interactions.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Sequence and ionic requirements of pUG fold quadruplexes.bioRxiv : the preprint server for biology · 2025
    Article
  13. Transposon Regulation in thebioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. RNA helicase unravels the secrets of germ granules.Nature structural & molecular biology · 2025
    Article
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Aditi Shukla *Department of Genetics, Blavatnik Institute at Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9743-4128
Jenny Yan *Department of Genetics, Blavatnik Institute at Harvard Medical School, Boston, MA, USA.
Daniel J PaganoDepartment of Genetics, Blavatnik Institute at Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6513-3870
Anne E DodsonDepartment of Genetics, Blavatnik Institute at Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7719-0496
Yuhan FeiDepartment of Genetics, Blavatnik Institute at Harvard Medical School, Boston, MA, USA.
Josh GorhamDepartment of Genetics, Blavatnik Institute at Harvard Medical School, Boston, MA, USA.
J G SeidmanDepartment of Genetics, Blavatnik Institute at Harvard Medical School, Boston, MA, USA.
Marvin WickensDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-0593-5740
Scott KennedyDepartment of Genetics, Blavatnik Institute at Harvard Medical School, Boston, MA, USA. kennedy@genetics.med.harvard.edu.ORCID http://orcid.org/0000-0002-7974-8155
Harvard University · USNanjing Agricultural University · CNUniversity of Wisconsin–Madison · US

Funding

FUNCTION OF POLY(A) AND 3'UTRSR01GM050942 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WICKENS, MARVIN P. · 1994 to 2020
$8.3M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Small Regulatory RNA Functions In The NucleusR01GM088289 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KENNEDY, SCOTT G · 2009 to 2022
$4.4M
Genetics and Genomics PhD Training GrantT32GM096911 · NIGMS · HARVARD MEDICAL SCHOOL · PI KENNEDY, SCOTT G · 2011 to 2020
$2.5M
Spatiotemporal Regulation of Liquid-like Condensates in the GermlineR01GM132286 · NIGMS · HARVARD MEDICAL SCHOOL · PI KENNEDY, SCOTT G · 2019 to 2022
$1.4M
Vesicular Trafficking of RNA from the Soma to the GermlineF32GM125345 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAGANO, DANIEL · 2017 to 2017
$59k
NIGMS NIH HHS F32 GM125345NIGMS NIH HHS R01 GM050942NIGMS NIH HHS R01 GM088289NIGMS NIH HHS R01 GM132286NIGMS NIH HHS T32 GM096911NIH HHS P40 OD010440
6 · The paper itself

Abstract

Mobile genetic elements threaten genome integrity in all organisms. RDE-3 (also known as MUT-2) is a ribonucleotidyltransferase that is required for transposon silencing and RNA interference in Caenorhabditis elegans

Indexed as

HeredityAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEpigenesis, GeneticGenomeGerm CellsMaleNucleotidyltransferasesPoly GPoly URNA-Dependent RNA PolymeraseRNA InterferenceRNA, MessengerRNA, Small InterferingTemplates, GeneticCaenorhabditis elegans Proteinsmut-2 protein, C elegansNucleotidyltransferasesPoly GPoly Upoly(U-G)RNA-Dependent RNA PolymeraseRNA, MessengerRNA, Small Interfering

Identifiers

PMID32499657
PMCPMC8396162
OpenAlexW3026710232

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.