ArticleNature2020
A positively selected FBN1 missense variant reduces height in Peruvian individuals.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
7.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.Genome biology · 2025Pooled it
- Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.Nature genetics · 2022Pooled it
- Fully exploiting SNP arrays: a systematic review on the tools to extract underlying genomic structure.Briefings in bioinformatics · 2022Pooled it
- Admixture mapping identifies African and Amerindigenous local ancestry loci associated with fetal growth.Human genetics · 2021Trial
- Article
- Rare protein-coding variation and the genetic architecture of height in >1.4 million individuals.medRxiv : the preprint server for health sciences · 2026Article
- QHAWAY: An Instance Segmentation and Monocular Distance Estimation ADAS for Vulnerable Road Users in Informal Andean Urban Corridors.Sensors (Basel, Switzerland) · 2026Article
- Genetic Variability in Child Growth Among South American Populations: A Perspective Integrating Population Genetics, Growth Standards, and Precision Growth Medicine.International journal of molecular sciences · 2025Review
- Subcontinental genetic variation in the All of Us Research Program: Implications for biomedical research.American journal of human genetics · 2025Article
- Genome of Kumamoto OysterEvolutionary applications · 2025Article
- Three-Dimensional Morphometric Analysis of Anterior Cerebral Circulation Aneurysms.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024Article
- Genetic associations with disease in populations with Indigenous American ancestries.Genetics and molecular biology · 2024Article
- Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies.Nature genetics · 2023Article
- Identification of two variants in PAX3 and FBN1 in a Chinese family with Waardenburg and Marfan syndrome via whole exome sequencing.Functional & integrative genomics · 2023Article
- Article
- Natural selection of immune and metabolic genes associated with health in two lowland Bolivian populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A Neanderthal/Denisovan GLI3 variant contributes to anatomical variations in mice.Frontiers in cell and developmental biology · 2023Article
- Molecular mechanisms underlying hematophagia revealed by comparative analyses of leech genomes.GigaScience · 2022Article
- The Association between Altitude and Waist-Height Ratio in Peruvian Adults: A Cross-Sectional Data Analysis of a Population-Based Survey.International journal of environmental research and public health · 2022Article
- The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density.Translational psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 9 institutions in 3 countries.
Samira AsgariCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2347-8985
Yang LuoCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7385-6166
Ali AkbariProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Gillian M BelbinThe Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Xinyi LiCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Daniel N HarrisProgram in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Martin SeligPathology Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Eric BartellProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Roger CalderonSocios En Salud, Lima, Peru.ORCID http://orcid.org/0000-0001-8932-0489
Kamil SlowikowskiCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2843-6370
Carmen ContrerasSocios En Salud, Lima, Peru.
Rosa YatacoSocios En Salud, Lima, Peru.
Jerome T GaleaSchool of Social Work, University of South Florida, Tampa, FL, USA.
Judith JimenezSocios En Salud, Lima, Peru.
Julia M CoitDepartment of Global Health and Social Medicine, and Division of Global Health Equity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Chandel FarroñaySocios En Salud, Lima, Peru.ORCID http://orcid.org/0000-0002-3532-3120
Rosalynn M NazarianPathology Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Timothy D O'ConnorProgram in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Harry C DietzDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6856-0165
Joel N HirschhornProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Heinner GuioInstituto Nacional de Salud, Lima, Peru.
Leonid LeccaSocios En Salud, Lima, Peru.
Eimear E KennyThe Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Esther E FreemanDepartment of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Megan B MurrayDepartment of Global Health and Social Medicine, and Division of Global Health Equity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Soumya RaychaudhuriCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.ORCID http://orcid.org/0000-0002-1901-8265
Broad Institute · USEsSALUD · PEHarvard University · USBrigham and Women's Hospital · USGenomic Health (United States) · USUniversity of Maryland, Baltimore · USHoward Hughes Medical Institute · USInstituto Nacional de Salud · PEUniversity of South Florida · US
Funding
Metabolomics Core U19AI111224 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH, MURRAY, MEGAN B · 2015 to 2021
$20.4MTraining Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MCell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1MDiscovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4MPowering whole genome sequence-based genetic discovery for common human diseases- Extended 2021-2022.U01HG009088 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI LIN, XIHONG, NEALE, BENJAMIN MICHAEL · 2016 to 2021
$5.1MFunctionally specialized components of disease heritability in ENCODE dataU01HG009379 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L, RAYCHAUDHURI, SOUMYA · 2017 to 2021
$2.5MRapid Evolution of Genomic Architecture and Multi-omics TraitsR35HG010692 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI O'CONNOR, TIMOTHY DAVID · 2019 to 2023
$2.3MNHGRI NIH HHS R35 HG010692NHGRI NIH HHS T32 HG002295NHGRI NIH HHS U01 HG009088NHGRI NIH HHS U01 HG009379NIAID NIH HHS U19 AI111224NIAMS NIH HHS R01 AR063759NIDDK NIH HHS R01 DK075787
Abstract
On average, Peruvian individuals are among the shortest in the world
Indexed as
Mutation, MissenseSelection, GeneticAdipokinesBody HeightFemaleFibrillin-1Gene FrequencyGenome-Wide Association StudyHeredityHumansIndians, South AmericanMaleMicrofibrilsPeruAdipokinesFBN1 protein, humanFibrillin-1
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.