ArticleNature2020
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases.BMC medical genomics · 2022Pooled it
- Replication and meta-analyses nominate numerous eosinophilic esophagitis risk genes.The Journal of allergy and clinical immunology · 2021Pooled it
- Single-cell analysis of chromatin accessibility in the human intestine identifies regulatory programs and clarifies genetic associations in Crohn's disease.Nature genetics · 2026Article
- Sex-specific trajectories of nonlinear immune aging at single-cell level.Nature communications · 2026Article
- Role of chromatin remodeling and immunopharmacology in cancer therapy.Molecular medicine (Cambridge, Mass.) · 2026Review
- Metadomain and metaloop genome interactions in mammalian T cells.Cell reports · 2026Article
- Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cells.bioRxiv : the preprint server for biology · 2026Article
- Genome-Wide Cross-Trait Analysis in European Populations Reveals Shared Genetic Architecture of Chronic Obstructive Pulmonary Disease and the Allergy Spectrum.International archives of allergy and immunology · 2025Article
- Dissection of the trans-endocytosis and signal inhibition functions of CTLA-4 through the study of a disease-associated Y139C mutation.Cellular & molecular immunology · 2025Article
- Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells.Nature immunology · 2025Article
- Genome-wide identification and analysis of recurring patterns of epigenetic variation across individuals.Communications biology · 2025Article
- Review
- The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases.Nature reviews. Immunology · 2024Review
- Targeting the chromatin structural changes of antitumor immunity.Journal of pharmaceutical analysis · 2024Review
- Low-dose Interleukin-2 For Psoriasis Therapy Based on the Regulation of Th17/Treg Cell Balance in Peripheral Blood.Inflammation · 2023Article
- Single‑nucleotide polymorphism rs6592645 confers asthma risk through regulatingExperimental and therapeutic medicine · 2023Article
- Functional interrogation of lymphocyte subsets in alopecia areata using single-cell RNA sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth.BMC medicine · 2023Article
- Cross-disorder genetic analysis of immune diseases reveals distinct gene associations that converge on common pathways.Nature communications · 2023Article
- Genomic Analysis of Foxp3 Function in Regulatory T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023Review
Corrections and comments
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Authors and funding
27 authors at 7 institutions in 5 countries.
Rabab Nasrallah *Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
Charlotte J Imianowski *Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK. cji27@cam.ac.uk.
Lara Bossini-CastilloImmune Genomics Group, Wellcome Sanger Institute, Cambridge, UK.
Francis M GrantLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
Mikail DoganThe Jackson Laboratory, Farmington, CT, USA.
Lindsey PlacekThe Jackson Laboratory, Farmington, CT, USA.
Lina KozhayaThe Jackson Laboratory, Farmington, CT, USA.
Paula KuoLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
Firas SadiyahLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
Sarah K WhitesideLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
Maxwell R MumbachHoward Hughes Medical Institute and Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Dafni GlinosImmune Genomics Group, Wellcome Sanger Institute, Cambridge, UK.
Panagiota VardakaLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
Carly E WhyteLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
Teresa LozanoLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
Toshitsugu FujitaChromatin Biochemistry Research Group, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Hodaka FujiiChromatin Biochemistry Research Group, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.ORCID http://orcid.org/0000-0003-1296-4256
Adrian ListonLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
Simon AndrewsBioinformatics Group, The Babraham Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-5006-3507
Adeline CozzaniInserm UMR1277/CNRS9020, Institut pour la Recherche sur le Cancer de Lille, Lille, France.
Jie YangLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
Suman MitraInserm UMR1277/CNRS9020, Institut pour la Recherche sur le Cancer de Lille, Lille, France.
Enrico LugliHumanitas Clinical and Research Center, Milan, Italy.ORCID http://orcid.org/0000-0002-1964-7678
Howard Y ChangHoward Hughes Medical Institute and Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9459-4393
Derya UnutmazThe Jackson Laboratory, Farmington, CT, USA.
Gosia TrynkaImmune Genomics Group, Wellcome Sanger Institute, Cambridge, UK. gosia@sanger.ac.uk.ORCID http://orcid.org/0000-0002-6955-9529
Rahul RoychoudhuriLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK. rr257@cam.ac.uk.
Babraham Institute · GBJackson Laboratory · USWellcome Sanger Institute · GBCentre National de la Recherche Scientifique · FRHirosaki University · JPHoward Hughes Medical Institute · USHumanitas University · IT
Funding
Technology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infectionU19AI142733 · NIAID · JACKSON LABORATORY · PI Anna Karolina Palucka · 2019 to 2026
$23.1MSpecial EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2MCenter for Personal Dynamic RegulomesRM1HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2019 to 2023
$13.8MDecoding Immunological perturbations during Chronic Fatigue SyndromeR01AI121920 · NIAID · JACKSON LABORATORY · PI UNUTMAZ, DERYA · 2016 to 2020
$3.3MBiotechnology and Biological Sciences Research Council BB/N007794/1Biotechnology and Biological Sciences Research Council BBS/E/B/000C0407Biotechnology and Biological Sciences Research Council BBS/E/B/000C0409Cancer Research UK 22597Medical Research Council MC_UU_00014/5Medical Research Council MR/N014995/1Medical Research Council MR/S024468/1Medical Research Council MR/S024468/2NHGRI NIH HHS P50 HG007735NHGRI NIH HHS RM1 HG007735NIAID NIH HHS R01 AI121920NIAID NIH HHS U19 AI142733Wellcome Trust 105663Wellcome Trust 105663/Z/14/ZWellcome Trust 206194Wellcome Trust 208363/Z/17/ZWellcome Trust WT206194
Abstract
Genetic variations underlying susceptibility to complex autoimmune and allergic diseases are concentrated within noncoding regulatory elements termed enhancers
Indexed as
AcetylationAllelesAnimalsChromosomes, Human, Pair 11Chromosomes, MammalianColitisEnhancer Elements, GeneticFemaleForkhead Transcription FactorsGenetic Predisposition to DiseaseHistonesHumansMembrane ProteinsMiceSyntenyT-Lymphocytes, RegulatoryForkhead Transcription FactorsFoxp3 protein, mouseHistonesLRRC32 protein, humanLrrc32 protein, mouseMembrane Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.