ArticleNature2020
BCR selection and affinity maturation in Peyer's patch germinal centres.
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Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
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Who cites it
62 citing papers in PubMed, 118 citations in OpenAlex.
- Peripheral B-cell receptor immunoglobulin heavy chain repertoire as a potential biomarker for frequently relapsing nephrotic syndrome in children.Renal failure · 2026Article
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- Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human VProceedings of the National Academy of Sciences of the United States of America · 2026Article
- A bio-inspired computational pipeline for antibody screening and repurposing.Briefings in bioinformatics · 2026Article
- Class switched bovine ultralong CDR H3 amplicons versus canonical in immune and non-immune tissues.Immunogenetics · 2026Article
- The multilayered identity of B cell memory.Cellular & molecular immunology · 2026Review
- Identification of immunogenic commensal antigens using phage display.Nature protocols · 2026Review
- Chromatin folding principles underlying the generation of antibody diversity.Molecular cell · 2026Article
- The B-cell-autoantibody axis in lung cancer immunity.Theranostics · 2026Review
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- Microbiota modulate immune cell populations and drive dynamic structural changes in gut-associated lymphoid tissue.Gut microbes · 2025Article
- Dynamics of local B cell migration during affinity maturation in the human tonsil.bioRxiv : the preprint server for biology · 2025Article
- In situ profiling of plasma cell clonality with image-based single-cell transcriptomics.bioRxiv : the preprint server for biology · 2025Article
- The influence of the gut microbiota on B cells in autoimmune diseases.Molecular medicine (Cambridge, Mass.) · 2025Review
- Embracing Interpersonal Variability of Microbiome in Precision Medicine.Phenomics (Cham, Switzerland) · 2025Article
- Mechanisms conferring multi-layered protection against intestinal Salmonella Typhimurium infection.FEMS microbiology reviews · 2025Review
- Bacterial and host fucosylation maintain IgA homeostasis to limit intestinal inflammation in mice.Nature microbiology · 2025Article
- Gut-lung axis in asthma and obesity: role of the gut microbiome.Frontiers in allergy · 2025Review
- Whole-genome sequencing reveals cellular origin of concomitant chronic lymphocytic leukemia and multiple myeloma: a case report.Cancer biology & therapy · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Huan Chen *Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Yuxiang Zhang *Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Adam Yongxin Ye *Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Zhou DuProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Mo XuMolecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.
Cheng-Sheng LeeProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0765-2410
Joyce K HwangProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Nia KyritsisProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Zhaoqing BaProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Donna NeubergDepartment of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.
Dan R LittmanMolecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.
Frederick W AltProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. alt@enders.tch.harvard.edu.ORCID http://orcid.org/0000-0002-0583-1271
Boston Children's Hospital · USHoward Hughes Medical Institute · USDana-Farber Cancer Institute · US
Funding
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI A. Heather Eliassen · 1985 to 2026
$330.6MOverall Priority Score P41GM103694 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D · 2013 to 2018
$6.9MPostdoctoral Training Program in AIDS-related ResearchT32AI007386 · NIAID · DANA-FARBER CANCER INSTITUTE · PI CANTOR, HARVEY, ENGELMAN, ALAN N. · 1990 to 2023
$5.3MMechanisms that Regulate Antibody Class Switch Recombination and Somatic HypermutationR37AI077595 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Frederick W. Alt · 2019 to 2026
$4.6MMolecular Mechanisms of Class Switch RecombinationR01AI077595 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI ALT, FREDERICK W. · 2009 to 2018
$4.3MA network model of the gut host-microbe ecosystem in Inflammatory Bowel DiseaseR01DK103358 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BONNEAU, RICHARD A, LITTMAN, DAN · 2014 to 2018
$3.2MProtein-Glycan Interaction Resource of the CFGR24GM098791 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D, PAULSON, JAMES C · 2011 to 2013
$2.6MMechanisms by which DNA sequence directs AID-mediated mutagenesis of Ig lociF30AI114179 · NIAID · HARVARD MEDICAL SCHOOL · PI HWANG, JOYCE KESHIN · 2015 to 2018
$164kHoward Hughes Medical InstituteNCI NIH HHS P30 CA006516NIAID NIH HHS F30 AI114179NIAID NIH HHS R01 AI077595NIAID NIH HHS R37 AI077595NIAID NIH HHS T32 AI007386NIDDK NIH HHS R01 DK103358NIGMS NIH HHS P41 GM103694NIGMS NIH HHS R24 GM098791NIH HHS F30AI114179-01A1
Abstract
The antigen-binding variable regions of the B cell receptor (BCR) and of antibodies are encoded by exons that are assembled in developing B cells by V(D)J recombination
Indexed as
AnimalsAntibody AffinityFecesGastrointestinal MicrobiomeGenes, Immunoglobulin Heavy ChainGerm-Free LifeGerminal CenterHomeostasisHumansImmunoglobulin Variable RegionMicePeyer's PatchesReceptors, Antigen, B-CellSelection, GeneticSomatic Hypermutation, ImmunoglobulinV(D)J RecombinationImmunoglobulin Variable RegionReceptors, Antigen, B-Cell
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.