ArticleNature2020
CRISPR screen in regulatory T cells reveals modulators of Foxp3.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers.
0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
169 citing papers in PubMed, 228 citations in OpenAlex.
- Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence.Nature communications · 2025Trial
- High-Content CRISPR Screening: Methods and Applications.MedComm · 2026Review
- SIRT2-mediated deacetylation activates USP22 catalytic function for PD-L1 protein stabilization and tumor immune escape.The Journal of clinical investigation · 2026Article
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- Metadomain and metaloop genome interactions in mammalian T cells.Cell reports · 2026Article
- Decoding the Oncogenic Role of USP22 Through Pan-Cancer Genomic and Epigenetic Analysis.Cancer reports (Hoboken, N.J.) · 2026Article
- Roles of ubiquitin‑specific peptidase 22 in cellular fate: From embryonic survival to tissue repair, inflammation and metabolism (Review).International journal of molecular medicine · 2026Review
- Bioengineered anti-EpCAM-guided exosome nanocarriers delivering Foxp3 agonist butyrate achieve tissue-specific immunomodulation in autoimmune Sjögren's syndrome.Journal of nanobiotechnology · 2026Article
- Insights into the structure and evolution of the human SAGA complex by affinity-ligand purification.Science advances · 2026Article
- Ubiquitin-centered post-translational modification crosstalk orchestrates tumor immunity and immunotherapy response.Experimental hematology & oncology · 2026Review
- Review
- Review
- FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry.Immunity · 2026Article
- Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance.Science advances · 2026Article
- Ubiquitin-Modifying Enzymes as Cell-Fate Regulators in Intestinal Inflammation.International journal of biological sciences · 2026Review
- Revealing the pathogenesis of autoimmune hepatitis and research progress in drug discovery from hepatic immune cells and intercellular communication signaling mechanisms.Frontiers in immunology · 2026Review
- Targeting USP22 reprograms the tumor microenvironment and sensitizes KRAS/p53-driven lung cancer to anti-PD-1 immunotherapy.Theranostics · 2026Article
- The role of miRNAs in the development of Super-Tregs as a potential therapy for neurodegenerative diseases.Frontiers in immunology · 2026Review
- Decoding Treg diversity and dysfunction to advance Treg-based therapies in autoimmune and inflammatory diseases.Frontiers in immunology · 2026Review
- Targeting ubiquitin-specific peptidase 22 in solid tumours: from ubiquitination to immunotherapy.Frontiers in cell and developmental biology · 2026Review
109 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 4 institutions in 2 countries.
Jessica T Cortez *Biomedical Sciences Graduate Program, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6314-7267
Elena Montauti *Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Eric ShifrutDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Jovylyn GatchalianMolecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Yusi ZhangDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Oren ShakedDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Yuanming XuDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Theodore L RothBiomedical Sciences Graduate Program, University of California, San Francisco, CA, USA.
Dimitre R SimeonovBiomedical Sciences Graduate Program, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1693-8664
Yana ZhangDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Siqi ChenRobert H. Lurie Comprehensive Cancer Center, Department of Medicine-Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9498-3823
Zhongmei LiDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Jonathan M WooDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Josephine HoMolecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Ian A VogelDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Grace Y PratorDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Bin ZhangRobert H. Lurie Comprehensive Cancer Center, Department of Medicine-Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Youjin LeeDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Zhaolin SunDepartment of Pharmacology, Dalian Medical University School of Pharmacy, Dalian, China.
Igal IferganDepartment of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Frédéric Van GoolDiabetes Center, University of California, San Francisco, CA, USA.
Diana C HargreavesMolecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Jeffrey A BluestoneDiabetes Center, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8793-7848
Alexander MarsonDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA. alexander.marson@ucsf.edu.ORCID http://orcid.org/0000-0002-2734-5776
Deyu FangDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. fangd@northwestern.edu.
University of California, San Francisco · USNorthwestern University · USSalk Institute for Biological Studies · USDalian Medical University · CN
Funding
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MSalk Institute Cancer Training GrantT32CA009370 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Diana Clare Hargreaves, Jan Karlseder · 1986 to 2026
$8.6MPREDOCTORAL TRAINING IN BIOMEDICAL SCIENCEST32GM008568 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANSEL, KARL MARK · 1995 to 2019
$6.3MThe role of BAF related complexes in regulatory T cell development and functionR01AI151123 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI HARGREAVES, DIANA CLARE, ZHENG, YE · 2020 to 2024
$4.0MFilling a Void of Research (FAVOR) Training for Transplant SurgeonsT32AI125222 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PETER G STOCK, Minnie M Sarwal · 2016 to 2026
$3.4MThe roles of Sirt1, a deacetylase, in immune tolerance and autoimmunityR01AI079056 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI FANG, DEYU · 2008 to 2017
$3.3MEpigenetic regulation of embryonic stem cells by ATP-dependent BAF chromatin remodeling complexesR35GM128943 · NIGMS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI HARGREAVES, DIANA CLARE · 2018 to 2022
$2.5MTargeting a Treg deubiquitinase in antitumor immune therapyR01CA232347 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FANG, DEYU · 2018 to 2022
$1.7MThe roles of Synoviolin in immune tolerance and autoimmunityR01AI108634 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FANG, DEYU · 2014 to 2017
$1.5MNCI NIH HHS F31 CA220801NCI NIH HHS K99 CA184043NCI NIH HHS P30 CA014195NCI NIH HHS R00 CA184043NCI NIH HHS R01 CA232347NCI NIH HHS T32 CA009370NIAID NIH HHS R01 AI079056NIAID NIH HHS R01 AI108634NIAID NIH HHS R01 AI151123NIAID NIH HHS R56 AI079056NIAID NIH HHS T32 AI007334NIAID NIH HHS T32 AI125222NIDDK NIH HHS P30 DK063720NIGMS NIH HHS F32 GM128377NIGMS NIH HHS R35 GM128943NIGMS NIH HHS T32 GM007618NIGMS NIH HHS T32 GM008568NIH HHS S10 OD018174NIH HHS S10 OD021822
Abstract
Regulatory T (T
Indexed as
CRISPR-Cas SystemsAnimalsAutoimmunityCells, CulturedForkhead Transcription FactorsGene EditingGene Expression RegulationHumansImmunotherapyMaleMiceNeoplasmsProtein StabilityReproducibility of ResultsT-Lymphocytes, RegulatoryUbiquitin-Protein LigasesForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouseRNF20 protein, humanRNF20 protein, mouseUbiquitin-Protein LigasesUbiquitin ThiolesteraseUsp22 protein, humanUSP22 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.