ArticleNature2020
A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes.
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Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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0cells of the map it votes in
105citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
105 citing papers in PubMed, 130 citations in OpenAlex.
- Dual-Target Cardiac Regeneration: ControllableCirculation · 2026Article
- The interaction between NPMc+ and Orai1 induces abnormal calcium influx to facilitate leukemogenesis.The FEBS journal · 2026Article
- Maternal Exercise and Offspring Cardiac Regenerative Potential: Roles of Apelin and α-Ketoglutarate.Biology · 2026Review
- Cardiac immunity and heart repair: Mechanism, challenge, and future direction.Chinese medical journal · 2026Review
- Sequential changes in calcium transients during M phase regulate cardiomyocyte proliferation.The Journal of cell biology · 2026Article
- Signaling pathways regulating cardiac regeneration.Cell regeneration (London, England) · 2026Review
- PCPE-1 promotes cardiac fibrosis with aging and obesity.JCI insight · 2026Article
- Biologics for cardiovascular diseases: from bench to bedside.Signal transduction and targeted therapy · 2026Review
- Single-cell transcriptomics and machine learning identify RNF144B and C5AR1 as immune-related molecular signatures and therapeutic targets in myocardial infarction.Genes & genomics · 2026Article
- Review
- Cell-cycle regulation of sarcomere integrity-Role for Actn2 phosphorylation.Physiological reports · 2026Article
- Inhibiting L-type calcium channel promotes cardiomyocyte proliferation through activating the canonical Wnt signaling pathway.Acta pharmacologica Sinica · 2026Article
- An Integrated Evaluation Framework for Adult Heart Regeneration.Journal of cellular and molecular medicine · 2026Article
- Cell-free strategies for cardiomyocyte proliferation and heart repair.Pharmacological reports : PR · 2026Review
- Cullin-associated and neddylation-dissociated protein 1 (CAND1) promotes cardiomyocyte proliferation and heart regeneration by enhancing the ubiquitinated degradation of Mps one binder kinase activator 1b (Mob1b).Cell death and differentiation · 2025Article
- Cardiomyocyte maturation and proliferation is a flip coin.BMC cardiovascular disorders · 2025Review
- Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation.Nature reviews. Cardiology · 2025Review
- Review
- Review
- Sirt4 Deficiency Promotes Cardiomyocyte Proliferation and Cardiac Repair.Journal of cellular and molecular medicine · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 6 institutions in 3 countries.
Ngoc Uyen Nhi NguyenDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-0694-3176
Diana C CansecoDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Feng XiaoDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yuji NakadaDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shujuan LiDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Nicholas T LamDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-9446-7378
Shalini A MuralidharDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jainy J SavlaDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Joseph A HillDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-5379-1614
Victor LeDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kareem A ZidanDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hamed W El-FekyDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zhaoning WangCenter for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mahmoud Salama AhmedDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Maimon E HubbiDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ivan Menendez-MontesDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-5252-9502
Jesung MoonDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shah R AliDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Victoria LeDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Elisa VillalobosDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Magid S MohamedDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Waleed M ElhelalyDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Suwannee ThetDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chukwuemeka George Anene-NzeluCardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Wilson Lek Wen TanCardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Roger S FooCardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Xun MengThe College of Life Sciences, Northwest University, Xi'an, China.
Mohammed KanchwalaEugene McDermott Center for Human Growth and Development/Center for Human Genetics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-6035-2970
Chao XingEugene McDermott Center for Human Growth and Development/Center for Human Genetics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-1838-0502
Jagoree RoyDepartment of Biology, Stanford University, Stanford, California, USA.
Martha S CyertDepartment of Biology, Stanford University, Stanford, California, USA.
Beverly A RothermelDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hesham A SadekDepartment of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. hesham.sadek@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-4745-366X
The University of Texas Southwestern Medical Center · USNational University of Singapore · SGCenter for Human Genetics · USStanford University · USNorthwest University · CNSouthwestern Medical Center · US
Funding
Training CoreP50HD087351 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, IANNACCONE, SUSAN T · 2020 to 2024
$8.0MTraining CoreU54HD087351 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI OLSON, ERIC N · 2015 to 2019
$7.8MTraining in Cardiovascular ResearchT32HL125247 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI JOSEPH A HILL · 2015 to 2026
$4.3MSystematic elucidation of calcineurin phosphatase signaling in humansR35GM136243 · NIGMS · STANFORD UNIVERSITY · PI Martha S. Cyert · 2020 to 2026
$3.9MModulating Calcineurin Signaling Pathways in MuscleR01HL072016 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHERMEL, BEVERLY A · 2003 to 2012
$3.7MRole of Meis1 in Regulation of Cardiomyocyte ProliferationR01HL115275 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SADEK, HESHAM · 2012 to 2016
$2.4MElevated mitochondrial fusion and function in Down syndrome - Revision - 2R01HD101006 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHERMEL, BEVERLY A · 2019 to 2022
$2.2MIdentifying The Human Calcineurin Signaling NetworkR01GM119336 · NIGMS · STANFORD UNIVERSITY · PI CYERT, MARTHA S. · 2016 to 2019
$2.0MRegulation of Cardiomyocyte Turnover in the Adult Mammalian HeartR01HL131778 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SADEK, HESHAM · 2016 to 2019
$1.6MCalcineurin Regulates Cardiomyocyte Cell Cycle Through Meis1 and Hoxb13R01HL147276 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SADEK, HESHAM · 2019 to 2022
$1.6MMechanisms of obesity-dependent alterations in cardiomyocyte metabolismR01HL128215 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2017 to 2020
$1.6MFoxO-dependent Control of Cardiovascular RemodelingR01HL126012 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2016 to 2019
$1.6MNHLBI NIH HHS R01 HL072016NHLBI NIH HHS R01 HL115275NHLBI NIH HHS R01 HL120732NHLBI NIH HHS R01 HL126012NHLBI NIH HHS R01 HL128215NHLBI NIH HHS R01 HL131778NHLBI NIH HHS R01 HL147276NHLBI NIH HHS T32 HL125247NICHD NIH HHS P50 HD087351NICHD NIH HHS R01 HD101006NICHD NIH HHS U54 HD087351NIGMS NIH HHS R01 GM119336NIGMS NIH HHS R35 GM136243NIH HHS S10 OD023552
Abstract
A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes
Indexed as
Cell ProliferationAnimalsAnimals, NewbornCalcineurinFemaleGene DeletionGene Expression RegulationHeartHomeodomain ProteinsMaleMiceMyeloid Ecotropic Viral Integration Site 1 ProteinMyocardiumMyocytes, CardiacProtein BindingRegenerationCalcineurinHomeodomain ProteinsHoxb13 protein, mouseMeis1 protein, mouseMyeloid Ecotropic Viral Integration Site 1 Protein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.