ArticleNature2020
Notch signalling drives synovial fibroblast identity and arthritis pathology.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 329 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
329citing papers in PubMed, 2 pooled it
42.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
329 citing papers in PubMed, 2 syntheses or guidelines pooled it, 507 citations in OpenAlex.
- A Comparison of the Properties of Mesenchymal Stem Cells Derived from Different Synovial Sources: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Insights into the pathogenesis of rheumatic and immune diseases from single-cell omics.Frontiers in immunology · 2026Pooled it
- Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis.Nature communications · 2025Trial
- Single-cell Transcriptomics in Autoimmune Diseases: Mechanistic Insights, Cross-disease Convergence, and Translational Challenges in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Type 1 Diabetes, and Multiple Sclerosis.Clinical reviews in allergy & immunology · 2026Review
- Accurate and well-powered case-control analysis of spatial molecular data.Nature methods · 2026Article
- From psoriatic plaque to synovium: decoding the skin-joint axis in psoriatic arthritis.Nature reviews. Rheumatology · 2026Review
- Enrichment and Proteomic Profiling of Stromal-Associated Extracellular Vesicle Subpopulations From Arthritic Synovial Fluid by Size-Exclusion Chromatography Coupled to CD90-Directed Immunocapture.Journal of extracellular vesicles · 2026Article
- Immune-mediated rheumatoid arthritis: from single-cell genomics to new therapies.Nature immunology · 2026Review
- A practical toolbox for modelling fibrosis in vitro.Nature biomedical engineering · 2026Review
- Endothelial PERK restricts lymphoid regeneration by reducing DLL4-NOTCH3 signaling at the Pre-B niche.Cell reports · 2026Article
- Identification and characterization of POSTNJournal of orthopaedic translation · 2026Article
- Identification of ferroptosis hub gene cDKN1A relating to immune microenvironment in rheumatoid arthritis via bioinformatic analysis and experimental verification.Clinical rheumatology · 2026Article
- An iguratimod prodrug reduces RA-FLS invasiveness by disrupting STAT1-C3-TNFα-mediated crosstalk between fibroblast-like synoviocytes and macrophages.Journal of orthopaedic translation · 2026Article
- Multi-Technique Integration Identifies O-GlcNAc Transferase in Fibroblast-Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Adipose-Joint Crosstalk in Obesity-Induced Osteoarthritis: Mechanisms, Biomarkers, and Translational Therapeutic Opportunities.Current rheumatology reports · 2026Review
- Inflammation-driven bone erosion and reactive remodeling in experimental arthritis revealed by cortical bone surface analysis.Arthritis research & therapy · 2026Article
- Signaling Pathway-Biomarker Coupling for Precision Therapy in Rheumatoid Arthritis: Mechanistic Insights, Translational Bottlenecks, and Emerging Strategies.ACR open rheumatology · 2026Review
- Cross-species integration of single-cell data reveals conserved pathology-associated cell populations across animal models and human samples.Cell reports methods · 2026Article
- MFAP5iScience · 2026Article
- Cellular crosstalk and signaling networks in the rheumatoid arthritis synovial microenvironment.Journal of translational medicine · 2026Review
269 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 18 institutions in 3 countries.
Kevin Wei *Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ilya Korsunsky *Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Jennifer L MarshallRheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.
Anqi GaoDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Gerald F M WattsDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Triin MajorRheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.ORCID http://orcid.org/0000-0003-3787-6068
Adam P CroftRheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.ORCID http://orcid.org/0000-0002-9487-0511
Jordan WattsDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Philip E BlazarDepartment of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Jeffrey K LangeDepartment of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Thomas S ThornhillDepartment of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Andrew FilerRheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.ORCID http://orcid.org/0000-0001-8164-6249
Karim RazaRheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.
Laura T DonlinArthritis and Tissue Degeneration, Hospital for Special Surgery, New York, NY, USA.ORCID http://orcid.org/0000-0002-1428-090X
Accelerating Medicines Partnership Rheumatoid Arthritis & Systemic Lupus Erythematosus (AMP RA/SLE) Consortium
Christian W SiebelDepartment of Discovery Oncology, Genentech, South San Francisco, CA, USA.
Christopher D BuckleyRheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.ORCID http://orcid.org/0000-0001-6924-6402
Soumya RaychaudhuriDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.ORCID http://orcid.org/0000-0002-1901-8265
Michael B BrennerDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. mbrenner@research.bwh.harvard.edu.
Brigham and Women's Hospital · USBroad Institute · USHospital for Special Surgery · USQueen Elizabeth Hospital Birmingham · GBUniversity of Rochester Medical Center · USNorthwestern University · USStanford University · USOklahoma Medical Research Foundation · USUniversity of Alabama at Birmingham · USUniversity of California San Diego · USUniversity of Colorado Denver · USUniversity of Pittsburgh · USVirginia Mason Medical Center · USBarts Health NHS Trust · GBNorthwell Health · USQueen Mary University of London · GBTokyo Medical and Dental University · JPUniversity of Massachusetts Chan Medical School · US
Funding
MECHANISMS OF ARTHRITIC &DERMATOLOGY DISORDERST32AR007530 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B. Brenner, Ellen M Gravallese · 1986 to 2026
$10.4MInstitutional Career Development CoreKL2TR002542 · NCATS · HARVARD MEDICAL SCHOOL · PI BREDELLA, MIRIAM ANTOINETTE, RUTKOVE, SEWARD B. · 2018 to 2022
$8.7MCYTOKINE REGULATION OF RA SYNOVIOCYTE PHENOTYPER01AR046713 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI IVASHKIV, LIONEL B · 1999 to 2025
$8.3MDiscovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4MMolecular and Cellular Dissection of Early Rheumatoid ArthritisUH2AR067694 · NIAMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI BRENNER, MICHAEL B., GREGERSEN, PETER K. · 2014 to 2020
$5.4MRA-SLE Molecular Deconstruction Leadership CenterUH2AR067677 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B., RAYCHAUDHURI, SOUMYA · 2014 to 2020
$4.3MExpanded fibroblast subset drives pathology in rheumatoid arthritisR01AR063709 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B., RAYCHAUDHURI, SOUMYA · 2015 to 2025
$3.3MSynovial Macrophage Transcriptional Signatures for Predicting Therapeutic EfficacyR01AR075423 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PERLMAN, HARRIS R · 2019 to 2023
$3.0MMacrophages in human autoimmune tissue pathologyR01AI148435 · NIAID · HOSPITAL FOR SPECIAL SURGERY · PI Laura T. Donlin · 2020 to 2026
$2.8MFunctionally specialized components of disease heritability in ENCODE dataU01HG009379 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L, RAYCHAUDHURI, SOUMYA · 2017 to 2021
$2.5MMolecular Pathways in Treatment Response and Flare in RAUH2AR067691 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI BYKERK, VIVIAN P, IVASHKIV, LIONEL B · 2014 to 2020
$2.0MDeciphering Pathways Driving Inflammatory Fibroblast Effector Functions in RAR01AR073833 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B. · 2019 to 2023
$1.9MMedical Research Council G0800648Medical Research Council G116/131Medical Research Council MR/R013926/1Medical Research Council MR/S025308/1Medical Research Council MR/S035850/1NCATS NIH HHS KL2 TR002542NHGRI NIH HHS U01 HG009379NIAID NIH HHS R01 AI148435NIAMS NIH HHS K08 AR077037NIAMS NIH HHS R01 AR046713NIAMS NIH HHS R01 AR063709NIAMS NIH HHS R01 AR063759NIAMS NIH HHS R01 AR073833NIAMS NIH HHS R01 AR075423NIAMS NIH HHS T32 AR007530NIAMS NIH HHS UH2 AR067677NIAMS NIH HHS UH2 AR067691NIAMS NIH HHS UH2 AR067694NIH HHS T32 AR007530-31Wellcome TrustWellcome Trust WT104551MA
Abstract
The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive, and destroys the joint
Indexed as
Signal TransductionAnimalsArthritis, RheumatoidEndothelial CellsFibroblastsHumansInflammationMaleMiceReceptor, Notch3Synovial MembraneThy-1 AntigensReceptor, Notch3Thy-1 Antigens
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.