ArticleScientific reports2020
Low vision and the risk of dementia: a nationwide population-based cohort study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- The eye-mind connection: a systematic review of retinal biomarkers and ocular signatures in major psychiatric disorders.European journal of medical research · 2025Pooled it
- Plaque-associated Microglial Polarization in Visual Brain Regions of the 5xFAD Mouse Model.bioRxiv : the preprint server for biology · 2026Article
- Plaque-associated microglial polarization in visual brain regions of the 5xFAD mouse model.Frontiers in aging neuroscience · 2026Article
- VI-OCR: "Visually Impaired" optical character recognition pipeline for text accessibility assessment.Scientific reports · 2025Article
- [Vision loss, cognitive decline and dementia-A narrative review article].Zeitschrift fur Gerontologie und Geriatrie · 2025Review
- Retinal microvascular alterations in motoric cognitive risk syndrome: an OCT angiography study.International ophthalmology · 2025Observational
- The Associations of Sensory Impairment With 10-Year Risk of Dementia and Alzheimer's Disease: The Health and Retirement Study, 2010-2020.Journal of geriatric psychiatry and neurology · 2025Article
- A comparison study of sensory processing in older adults with and without dementia.Turkish journal of medical sciences · 2025Article
- Melatonin: A potential nighttime guardian against Alzheimer's.Molecular psychiatry · 2025Review
- Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer's disease pathology in the eye clinic.Alzheimer's research & therapy · 2024Observational
- The associations of herpes simplex virus and varicella zoster virus infection with dementia: a nationwide retrospective cohort study.Alzheimer's research & therapy · 2024Article
- Article
- Influence of Sensory Impairments on Incidence of Dementia in the Korean Population.Psychiatry investigation · 2023Article
- Immunotherapy with Cleavage-Specific 12A12mAb Reduces the Tau Cleavage in Visual Cortex and Improves Visuo-Spatial Recognition Memory in Tg2576 AD Mouse Model.Pharmaceutics · 2023Article
- Cognitive Performance and Diabetic Retinopathy: What Your Eyes Can Reveal About Your Brain.Current diabetes reviews · 2023Article
- Decreased visual acuity is related to thinner cortex in cognitively normal adults: cross-sectional, single-center cohort study.Alzheimer's research & therapy · 2022Article
- Addition of Vision Impairment to a Life-Course Model of Potentially Modifiable Dementia Risk Factors in the US.JAMA neurology · 2022Article
- Longitudinal Changes in Hearing and Visual Impairments and Risk of Dementia in Older Adults in the United States.JAMA network open · 2022Article
- Concurrent vision and hearing impairment associated with cognitive dysfunction in a population aged 85+ years: the Ural Very Old Study.BMJ open · 2022Article
- Visual Impairment and Risk of Dementia in 2 Population-Based Prospective Cohorts: UK Biobank and EPIC-Norfolk.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies suggested that an association exists between vision loss and cognitive impairment, although it is still vague whether there are causal relationships or direct association between low vision and dementia. We were to investigate the association between low vision and dementia in the Korean population using the National Health Insurance Service (NHIS) database. We analyzed the data of 6,029,657 subjects aged ≥40 years, drawn from Korea National Health Insurance Service. The hazard ratio (HRs) and 95% confidence interval (CIs) of dementia, Alzheimer's disease (AD), and Vascular dementia (VD) were estimated using multivariable Cox proportional hazards regression models. Statistical analysis showed that subjects with more severe visual impairments have a higher risk of dementia, AD, and VD after adjusting for compounding variables. The HRs of dementia increased significantly as visual acuity worsened (HRs 1.444 [95% CIs 1.415-1.473] for visual acuity (VA) < 1.0, 1.734 [1.693-1.777] for VA < 0.3, 1.727 [1.686-1.770] for VA < 0.1 and 1.991[1.902-2.085] for visual loss). Baseline visual loss and visual impairment were positively associated with the risk of dementia, AD, and VD. From the results of this nationwide population-based cohort study, we suggest that there is a significant increase in the incidence of dementia in subjects with low vision.
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