Evidence map›Paper›PMID 32499527›Full record

ArticleNature communications2020

Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD

Donghyun Ka, Hyejin Oh, Eunyoung Park, Jeong-Han Kim, Euiyoung Bae

Abstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed.

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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Donghyun Ka *Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Korea.
Hyejin Oh *Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Korea.
Eunyoung ParkDepartment of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Korea.
Jeong-Han KimDepartment of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Korea.
Euiyoung BaeDepartment of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Korea. bae@snu.ac.kr.ORCID http://orcid.org/0000-0001-7865-0167

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intense arms race between bacteria and phages has led to the development of diverse antiphage defense systems in bacteria. Unlike well-known restriction-modification and CRISPR-Cas systems, recently discovered systems are poorly characterized. One such system is the Thoeris defense system, which consists of two genes, thsA and thsB. Here, we report structural and functional analyses of ThsA and ThsB. ThsA exhibits robust NAD

Indexed as

Bacillus cereusBacteriophagesCloning, MolecularCRISPR-Cas SystemsCrystallography, X-RayDNA Mutational AnalysisEscherichia coliHydrolasesKineticsMutationNADProtein DomainsProtein Structure, SecondaryToll-Like ReceptorsHydrolasesNADToll-Like Receptors

Identifiers

PMID32499527
PMCPMC7272460

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.