ArticleBMJ open gastroenterology2020
Acute appendicitis is associated with appendiceal microbiome changes including elevated
Article in BMJ open gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Distinct microbiota composition and dendritic cell activation in the appendix microenvironment of ulcerative colitis patients.Gut microbes · 2025Article
- The functional landscape of the appendix microbiome under conditions of health and disease.Gut pathogens · 2025Review
- Exploring the Immunological Role of the Microbial Composition of the Appendix and the Associated Risks of Appendectomies.Journal of personalized medicine · 2025Review
- Amuc_1100 pretreatment alleviates acute pancreatitis in a mouse model through regulating gut microbiota and inhibiting inflammatory infiltration.Acta pharmacologica Sinica · 2024Article
- The appendix and ulcerative colitis - an unsolved connection.Nature reviews. Gastroenterology & hepatology · 2023Review
- Appendicitis is associated with an increased risk of systemic lupus erythematosus: a nationwide, population-based, case-control study.Clinical rheumatology · 2023Article
- Retrospective cohort study of the impact of faecoliths on the natural history of acute appendicitis.World journal of emergency surgery : WJES · 2023Article
- Causal effects of gut microbiota on appendicitis: a two-sample Mendelian randomization study.Frontiers in cellular and infection microbiology · 2023Article
- Appendiceal microbiome in uncomplicated and complicated acute appendicitis: A prospective cohort study.PloS one · 2022Article
- The microbiome in adult acute appendicitis.Gut microbiome (Cambridge, England) · 2022Article
- Editorial: The Microbiome in Hepatobiliary and Intestinal Disease.Frontiers in physiology · 2022Article
- Hospitalization Trends for Acute Appendicitis in Spain, 1998 to 2017.International journal of environmental research and public health · 2021Observational
- Associations of hair cortisol concentrations with paediatric appendicitis.Scientific reports · 2021Article
- Acute appendicitis manifests as two microbiome state types with oral pathogens influencing severity.Gut microbesArticle
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare the appendiceal microbiomes and examine the prevalence of
designArchived samples of formalin-fixed paraffin-embedded appendiceal tissues were obtained from 50 consecutive female subjects who underwent appendectomy for acute, non-perforated appendicitis, and 35 consecutive female controls who underwent incidental appendectomy during gynaecological surgery.
results16S rRNA gene sequencing revealed that the relative abundances (RAs) of the major phyla in appendiceal tissues (Firmicutes, Proteobacteria, Bacteroidetes, and Actinobacteria) were similar in both groups. Beta diversity was significantly different due to differences in Bacteroidetes and Proteobacteria (p<0.0001). Within Proteobacteria, RAs of classes Alphaproteobacteria (~21%, fold change (FC)=1.31, false discovery rate (FDR) p value=0.03) and Epsilonproteobacteria (~1%, FC=0.25, FDR p value>0.05) were increased in acute appendicitis samples. RAs of unknown genera from families Burkholderiaceae and Enterobacteriaceae were decreased in appendicitis samples, and 14 genera were increased, including
conclusionsOur findings indicate that
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Registered trials
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