ArticleBMJ open2020
Early Psychosis Intervention-Spreading Evidence-based Treatment (EPI-SET): protocol for an effectiveness-implementation study of a structured model of care for psychosis in youth and emerging adults.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03919760 (Enhancing Evidence-Based Practice for Youth and Emerging Adults With Early Psychosis), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Enhancing Evidence-Based Practice for Youth and Emerging Adults With Early Psychosis: Implementation and Evaluation in Diverse Service Settings
Who cites it
9 citing papers in PubMed.
- Fidelity, Implementation Determinants, and Patient-Level Outcomes Following Initial Implementation of NAVIGATE in the Early Psychosis Intervention-Spreading Evidence-Based Treatment (EPI-SET) Study.Schizophrenia bulletin · 2026Article
- "Never Just the Next Case File": A Qualitative Study Exploring Youth and Family Experiences Within Early Psychosis Coordinated Specialty Care.Early intervention in psychiatry · 2026Article
- "A Connected Community": Evaluating the Use of Project ECHO to Support the Implementation of an Evidence-Based Early Psychosis Care Model.Schizophrenia bulletin open · 2025Article
- Standardizing Fidelity to Evidence-Based Practice in the Early Psychosis Intervention Network.Psychiatric services (Washington, D.C.) · 2024Article
- Are Small Teams a Viable Strategy to Deliver Early Psychosis Intervention Services in Rural Areas? An Ontario Fidelity Study.Healthcare policy = Politiques de sante · 2024Article
- A National Learning Health Experiment in Early Psychosis Research and Care.Psychiatric services (Washington, D.C.) · 2022Article
- The quick pivot: Capturing real world modifications for the re-implementation of an early psychosis program transitioning to virtual delivery.Frontiers in health services · 2022Article
- Adapting Evidence-Based Early Psychosis Intervention Services for Virtual Delivery: Protocol for a Pragmatic Mixed Methods Implementation and Evaluation Study.JMIR research protocols · 2021Article
- Quality of individual and group level interventions for first-episode psychosis at the tertiary psychiatric hospital in Uganda.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Funding
Abstract
introductionWhile early psychosis intervention (EPI) has proliferated in recent years amid evidence of its effectiveness, programmes often struggle to deliver consistent, recovery-based care. NAVIGATE is a manualised model of EPI with demonstrated effectiveness consisting of four components: individualised medication management, individual resiliency training, supported employment and education and family education. We aim to implement NAVIGATE in geographically diverse EPI programmes in Ontario, Canada, evaluating implementation and its effect on fidelity to the EPI model, as well as individual-level outcomes (patient/family member-reported and interviewer-rated), system-level outcomes (captured in provincial administrative databases) and engagement of participants with lived experience. METHODS AND ANALYSIS: This is a multisite, non-randomised pragmatic hybrid effectiveness-implementation type III mixed methods study coordinated at the Centre for Addiction and Mental Health (CAMH) in Toronto. Implementation is supported by the Provincial System Support Program, a CAMH-based programme with provincial offices across Ontario, and Extension of Community Healthcare Outcomes Ontario Mental Health at CAMH and the University of Toronto. The primary outcome is fidelity to the EPI model as measured using the First Episode Psychosis Services-Fidelity Scale. Four hundred participants in the EPI programmes will be recruited and followed using both individual-level assessments and health administrative data for 2 years following NAVIGATE initiation. People with lived experience will be engaged in all aspects of the project, including through youth and family advisory committees. ETHICS AND DISSEMINATION: Research ethics board approval has been obtained from CAMH and institutions overseeing the local EPI programmes. Study findings will be reported in scientific journal articles and shared with key stakeholders including youth, family members, programme staff and policymakers. TRIAL REGISTRATION NUMBER: NCT03919760; Pre-results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.