Evidence map›Paper›PMID 32499034›Full record

ReviewThe journal of allergy and clinical immunology. In practice2020

Food Allergy from Infancy Through Adulthood.

Scott H Sicherer, Christopher M Warren, Christopher Dant, Ruchi S Gupta, Kari C Nadeau

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in The journal of allergy and clinical immunology. In practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06261554 (Efficacy and Safety of Low-dose Sesame Oral Immunotherapy in Pediatric Patients), which is not on this map. Cited by 94 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 2 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06261554 narecruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy and Safety of Low-dose Sesame Oral Immunotherapy in Pediatric Patients: A Randomized Controlled Trial

TypeinterventionalSponsorMedical University of WarsawRan2024 to 2027Enrolled39ConditionsFood AllergyArmsDietary Supplement: Low dose OIT
3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 2 syntheses or guidelines pooled it, 224 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Confronting fear and uncertainty: adults' experiences of undergoing a food challenge test for food allergy.International journal of qualitative studies on health and well-being · 2026
    Article
  4. Feeding characteristics in young children with IgE-mediated food allergies: A cross-sectional observational study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Observational
  5. Prevalence and Sociodemographic Variation of Allergic Diseases in Australia: Findings From the Australian National Health Survey.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
  6. Context-dependent regulation of mast cell-mediated food allergy in C57BL/6J mice.The Journal of allergy and clinical immunology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Outcome Predictors of Oral Food Challenge in Children.Children (Basel, Switzerland) · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Microneedles in Allergy Immunotherapy: the Present and Future.Current allergy and asthma reports · 2025
    Review
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Scott H SichererDepartment of Pediatrics, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: scott.sicherer@mssm.edu.
Christopher M WarrenCenter for Food Allergy & Asthma Research, Lurie Children's Hospital, Northwestern University Feinberg School of Medicine, Chicago, Ill; Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, Calif.
Christopher DantSean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, Calif.
Ruchi S GuptaCenter for Food Allergy & Asthma Research, Lurie Children's Hospital, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Kari C NadeauSean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, Calif.
Stanford University · USIcahn School of Medicine at Mount Sinai · USLurie Children's Hospital · US

Funding

US Prevalence, Distribution and Determinants of Adult and Childhood Food AllergyR21AI135702 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI GUPTA, RUCHI S · 2018 to 2019
$433k
NIAID NIH HHS R21 AI135702
6 · The paper itself

Abstract

Food allergies are the result of immune responses that cause adverse reactions to foods. Immune responses to foods may produce a spectrum of symptoms and disorders, including acute allergic reactions and anaphylaxis, food protein-induced allergic proctocolitis, food protein-induced enterocolitis syndrome, food-dependent, exercise-induced anaphylaxis, and oral allergy syndrome (pollen-food allergy syndrome). Food-allergic responses also contribute to chronic inflammatory disorders such as eosinophilic esophagitis and atopic dermatitis. Although food allergy affects people from infancy through adulthood, there are allergic features that differ according to age (ie, presentation, triggers, and natural course) and have important implications for diagnosis, prognosis, and management. New food allergies can develop at any age, and we propose similarities in the etiology of de novo food allergy whether in infancy or adulthood. The approach to managing food allergy changes dramatically over the life course, and physicians and patients must respond accordingly to optimize care. Food allergy therapies are emerging, and the efficacy and safety of these interventions could differ by age group of those treated. In this review, we highlight interesting observations on the etiology and characteristics of food allergy presenting at different ages and discuss clinical management as it relates to life stage.

Indexed as

AnaphylaxisEnterocolitisFood HypersensitivityAdultAllergensHumansImmunoglobulin EInfantAllergensImmunoglobulin EIgENatural historyPeanut allergySkin prick test

Identifiers

PMID32499034
PMCPMC7899184
OpenAlexW3029817814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.