ArticleMaturitas2020
Multimorbidity in a cohort of middle-aged women: Risk factors and disease clustering.
Article in Maturitas, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Between Depression and Risk of Hypertension: A Systematic Review and Meta-Analysis.Brain and behavior · 2025Pooled it
- About half of older adults have two or more chronic conditions at the same time: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Determinants of multimorbidity in low- and middle-income countries: A systematic review of longitudinal studies and discovery of evidence gaps.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024Pooled it
- Age at Menopause and Trajectories of Multimorbidity Progression to Mortality: A Multi-State Analysis of UK Biobank Data.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Classification and Severity Assessment of Obesity in Clinical Risk Prediction of Multimorbidity Trajectories.Clinical obesity · 2026Article
- Health History, Health Condition, Health Behaviours and Health-Seeking Behaviours of Middle-Aged Women Living in a Modern Rural Community: A Survey Research.Nursing open · 2025Observational
- Overweight and Obesity and Multimorbidity in Community-Living Older Persons in the Philippines.Journal of the ASEAN Federation of Endocrine Societies · 2025Article
- Circadian rest-activity rhythms and multimorbidity and mortality risks among menopausal women: a trajectory analysis of a UK Biobank cohort.BMC public health · 2025Article
- The Influence of Mat Pilates Training on Cardiometabolic Risk Factors in Postmenopausal Women with Single or Multiple Cardiometabolic Diseases.International journal of environmental research and public health · 2025Article
- Modeling the spectrum and determinants of multimorbidity risk among older adults in India.PloS one · 2025Article
- Anti-Aging Tests for Middle Aged Women.Journal of menopausal medicine · 2024Review
- How the development of chronic morbidity and multimorbidity depends on natural age of menopause: Results from nationally representative cross-sectional Indian study.Journal of family medicine and primary care · 2024Article
- Determinants of multimorbidity in older adults in Iran: a cross-sectional study using latent class analysis on the Bushehr Elderly Health (BEH) program.BMC geriatrics · 2024Article
- Nutrient intake and risk of multimorbidity: a prospective cohort study of 25,389 women.BMC public health · 2024Article
- Association of educational attainment with hypertension and type-2 diabetes: A Mendelian randomization study.SSM - population health · 2024Article
- Gene co-expression networks reveal sex-biased differences in musculoskeletal ageing.Frontiers in aging · 2024Article
- Ethnic differences in multimorbidity after accounting for social-economic factors, findings from The Health Survey for England.European journal of public health · 2023Article
- Findings from the Indonesian family life survey on patterns and factors associated with multimorbidity.Scientific reports · 2023Article
- Prediction of Multimorbidity in Brazil: Latest Fifth of a Century Population Study.JMIR public health and surveillance · 2023Article
- Patterns and Predictors of Multimorbidity in the Azar Cohort.Archives of Iranian medicine · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to evaluate which risk factors in middle-aged women are associated with higher risk of multimorbidity in older age. STUDY
designWe conducted a prospective cohort study from 1990 to 1993 in Santiago de Chile, Chile among women aged 40-59 (at baseline). Diagnosed illnesses were retrieved from national health records in 2020.
main outcome measuresClinical and laboratory evaluation was conducted.
results1066 women were followed-up for a mean of 27.8 years, after which 49.7% presented multimorbidity. These women, as compared with those without multimorbidity, were more likely at baseline to have had obesity (20.4% vs. 8.6%, p < 0.001); be post-menopause (47.2% vs. 40.5%; p < 0.03); have jobs that did not require a qualification (74.2% vs. 56.0%, p < 0.001); arterial hypertension (19.8% vs 14.4%, p < 0.018); lower HDL-cholesterol (51.3 ± 12.9 vs. 53.6±12.7 mg/dL, p < 0.005); and higher triglyceride levels (136.0 ± 65.0 vs. 127.0 ± 74.0 mg/dL, p = 0.028). Hypertension was associated in 22.0% of women with diabetes, in 20.9% with osteoarthritis and 14.0% with depression. Osteoarthritis was also associated with diabetes mellitus (8.3%) and depression (7.8%). Diabetes mellitus, in addition to hypertension and osteoarthritis, was associated with depression (6.4%). In a logistic regression model, we observed that obesity in middle-aged women was the strongest risk factor for multimorbidity in the elderly (OR: 2.48; 95% CI, 1.71-3.61), followed by having a job that did not require a qualification (OR: 2.18; 95% CI, 1.67-2.83) and having a low HDL-cholesterol level (OR: 1.31; 95% CI, 1.02-1.68).
conclusionsMultimorbidity was highly prevalent in this older female population. Obesity in middle-aged women was the strongest risk factor for multimorbidity at older age. These results are relevant for Chile and other countries with similar population profiles.
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