ArticleNutrition journal2020
Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study.
Article in Nutrition journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Paternal folate deficiency reveals meiosis as a metabolic sensing window in the male germline.bioRxiv : the preprint server for biology · 2026Article
- Atlas of one-carbon metabolism in conventional and germ-free mice reveals folate as a key determinant of biochemical pathways.Nature metabolism · 2026Article
- Association between dietary folate intake and obesity in children and adolescents: a cross-sectional NHANES study.BMC pediatrics · 2026Article
- Novel Anthropometric Indices and Probability of Adequate Nutrient Intake in the Older Polish Population.Nutrients · 2025Article
- Association between abdominal obesity and nutritional supplement use among Iranian adults in the Shahedieh cohort study.Scientific reports · 2025Article
- Article
- Integrated bioinformatics reveals genetic links between visceral obesity and uterine tumors.Molecular genetics and genomics : MGG · 2024Article
- A new framework for exploratory network mediator analysis in omics data.Genome research · 2024Article
- Multiomics Picture of Obesity in Young Adults.Biology · 2024Article
- Association between Variation in Body Fat Mass Magnitude and Intake of Nutrients, including Carbohydrates, Fat, and B Vitamins, in a Cohort of Highly Trained Female Athletes.Foods (Basel, Switzerland) · 2023Article
- Article
- Statistical Approaches to Study Exposome-Health Associations in the Context of Repeated Exposure Data: A Simulation Study.Environmental science & technology · 2023Article
- The Effect of Folic Acid Supplementation on Endothelial Function and Arterial Stiffness Markers in Adults: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2023Article
- Association of the DNA Methylation of Obesity-Related Genes with the Dietary Nutrient Intake in Children.Nutrients · 2023Article
- Article
- Association between android fat mass, gynoid fat mass and cardiovascular and all-cause mortality in adults: NHANES 2003-2007.Frontiers in cardiovascular medicine · 2023Article
- Micronutrients Deficiencies in Candidates of Bariatric Surgery: Results from a Single Institution over a 1-Year Period.Obesity surgery · 2023Article
- Methylenetetrahydrofolate Reductase C677T Gene Variant in Relation to Body Mass Index and Folate Concentration in a Polish Population.Biomedicines · 2022Article
- Serum Folate Related to Five Measurements of Obesity and High-Sensitivity C-Reactive Protein in Korean Adults.Nutrients · 2022Article
- Suppression of high-fat-diet-induced obesity in mice by dietary folic acid supplementation is linked to changes in gut microbiota.European journal of nutrition · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe link between folate metabolism and obesity has recently been underlined, suggesting that folate deficiency may lead to body weight gain and adiposity. We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity.
methodsA case-control study including 421 healthy participants (aged 20-40) was performed in Poznań, Poland. The cases were 213 subjects with BMI > 25 kg/m
resultsSubjects with overweight and obesity had 12% lower folate intake (p < 0.05) and 8.5% lower folate serum concentrations (p < 0.01) than the controls. Serum folate concentrations and folate intake were inversely associated with body fat percentage (p < 0.05) and waist circumference (p < 0.05 and p < 0.001, respectively). Serum folate concentration, though not folate intake, was negatively associated with WHR and BMI (p < 0.05, for both associations).
conclusionsLower folate intake and serum levels are weakly, but independently, associated with greater body weight and central adiposity in people aged 20-40. MTHFR and DHFR polymorphism seems not to have significant impact on body weight.
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Registered trials
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