ArticleBMC pediatrics2020
Combination of gamma-glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages: a retrospective analysis of 282 infants.
Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Use of shear wave elastography for the diagnosis and follow-up of biliary atresia: A meta-analysis.World journal of gastroenterology · 2022Pooled it
- The diagnostic performance of ultrasound elastography for biliary atresia: A meta-analysis.Frontiers in public health · 2022Pooled it
- [Diagnostic value and clinical significance of matrix metalloproteinase-7, gamma-glutamate transferase, and liver stiffness measurement with ultrasound elastography in children with biliary atresia].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Article
- ULTRASONOGRAPHY, SHEAR WAVE ELASTOGRAPHY AND LIVER HISTOLOGY FOR THE DIFFERENTIAL DIAGNOSIS BETWEEN BILIARY ATRESIA AND OTHER CAUSES OF CHOLESTASIS.Arquivos de gastroenterologia · 2026Article
- Does Gamma-Glutamyl Transpeptidase Serum Level Play a Role as a Prognostic Marker in Biliary Atresia, an Immune-Mediated Cholangiopathy in Children?Journal of clinical medicine · 2025Article
- Application of machine learning in constructing a diagnostic model for neonatal biliary atresia.Pediatric investigation · 2025Article
- Clinical presentations and outcomes of pancreaticobiliary maljunction in different pediatric age groups.BMC pediatrics · 2023Article
- Diagnostic Efficacy of Advanced Ultrasonography Imaging Techniques in Infants with Biliary Atresia (BA): A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2022Review
- Biliary atresia and congenital disorders of the extrahepatic bile ducts.World journal of gastrointestinal pharmacology and therapeutics · 2022Review
- The utility of shear wave elastography and serum biomarkers for diagnosing biliary atresia and predicting clinical outcomes.European journal of pediatrics · 2022Article
- A Novel Model for Predicting the Clearance of Jaundice in Patients With Biliary Atresia After Kasai Procedure.Frontiers in pediatrics · 2022Article
- Low gamma-glutamyl transpeptidase levels at presentation are associated with severity of liver illness and poor outcome in biliary atresia.Frontiers in pediatrics · 2022Article
- Utility of Transient Elastography in Differentiating Biliary Atresia from Other Causes of Neonatal Cholestasis: A Prospective Observational Study.Journal of clinical and experimental hepatologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThis study aims to explore the diagnostic accuracy of the combination of gamma-glutamyl transferase (GGT) and liver stiffness measurement (LSM) for biliary atresia (BA) screening at different ages.
methodsOur retrospective study involved 282 infants under the age of 120 days with jaundice who were admitted into Beijing Children's Hospital between January 2016 to December 2018. The GGT and LSM levels of infants were obtained. A parallel test was used, and ROC curve was created to obtain cutoff values of GGT and LSM for BA infants at different ages.
resultsOf the 282 infants, 135 were diagnosed with BA and 147 were non-BA infants. In all age groups (A: ≤60 days; B: 61-90 days; C: 91-120 days), the LSM and GGT levels of the BA group were significantly higher than that of the non-BA group, P < 0.05. The cutoff value of GGT and LSM to diagnosis BA was 191.2 U/L, 213.2 U/L, 281.5 U/L and 7.5 kPa, 10.0 kPa, 11.0 kPa in groups A, B and C, respectively. The parallel test was used to determine a sensitivity of 97.3, 98.1 and 100% in group A, B and C when either GGT or LSM levels were met in BA infants. The sensitivities of parallel testing for group A and B were higher than LSM or GGT used alone.
conclusionsCutoff values of GGT and LSM to screen BA increased with age. Parallel testing of GGT and LSM in infants who are younger than 90 days old can decrease the rate of BA misdiagnosis.
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