Evidence map›Paper›PMID 32498429›Full record

ArticleGenes2020

3'-UTR Polymorphisms of Vitamin B-Related Genes Are Associated with Osteoporosis and Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women.

Tae-Keun Ahn, Jung Oh Kim, Hui Jeong An, Han Sung Park, Un Yong Choi, Seil Sohn, Kyoung-Tae Kim, Nam Keun Kim, In-Bo Han

Open access · goldAbstract read
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Role of vitamins in the development and treatment of osteoporosis (Review).International journal of molecular medicine · 2025
    Review
  2. Role of vitamins beyond vitamin DInternational journal of molecular medicine · 2024
    Review
  3. Article
  4. Article
  5. Bone Health in Patients with Dyslipidemias: An Underestimated Aspect.International journal of molecular sciences · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Association ofGenes · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Tae-Keun AhnDepartment of Orthopedics, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea.ORCID 0000-0001-9177-1692
Jung Oh KimTheragen Bio Co., Ltd. 145, Gwanggyo-ro, Yeongtong-gu, Suwon 16229, Korea.ORCID 0000-0002-4171-2034
Hui Jeong AnDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Korea.
Han Sung ParkDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Korea.
Un Yong ChoiDepartment of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea.ORCID 0000-0001-9331-1112
Seil SohnDepartment of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea.
Kyoung-Tae KimDepartment of Neurosurgery, School of Medicine, Kyungpook National University, Daegu 41944, Korea.ORCID 0000-0003-4867-6854
Nam Keun KimDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Korea.
In-Bo HanDepartment of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea.ORCID 0000-0003-0541-3528
CHA University Bundang Medical Center · KRCHA University · KRKyungpook National University Hospital · KRTheragen · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As life expectancy increases, the prevalence of osteoporosis is increasing. In addition to vitamin D which is well established to have an association with osteoporosis, B vitamins, such as thiamine, folate (vitamin B9), and cobalamin (vitamin B12), could affect bone metabolism, bone quality, and fracture risk in humans by influencing homocysteine/folate metabolism. Despite the crucial role of B vitamins in bone metabolism, there are few studies regarding associations between B vitamin-related genes and osteoporosis. In this study, we investigated the genetic association of four single nucleotide polymorphisms (SNPs) within the 3'-untranslated regions of vitamin B-related genes, including

Indexed as

3' Untranslated RegionsAllelesAntigens, CDFemaleFolic AcidFractures, CompressionGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMembrane Transport ProteinsOsteoporosisOsteoporotic FracturesPostmenopauseReceptors, Cell SurfaceReduced Folate Carrier Protein3' Untranslated RegionsAntigens, CDCD320 protein, humanFolic AcidMembrane Transport ProteinsReceptors, Cell SurfaceReduced Folate Carrier ProteinSLC19A1 protein, humanSLC19A2 protein, humanTCN2 protein, humanTranscobalaminsVitamin B 12Vitamin B Complexcobalamincompression fracturefolatehomocysteineosteoporosispolymorphism

Identifiers

PMID32498429
PMCPMC7349196
OpenAlexW3033359145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.