ReviewInternational journal of molecular sciences2020
Clinical Trials of Stem Cell Treatment for Spinal Cord Injury.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05831163 (A Review of Clinical Trial Experiences and Trends From Spinal Cord Injury Patients), which is not on this map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Review of Clinical Trial Experiences and Trends From Spinal Cord Injury Patients
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment of mesenchymal stem cells for the treatment of spinal cord injury: a systematic review and network meta-analysis.Frontiers in cellular neuroscience · 2025Pooled it
- Review
- Repairing spinal cord injuries: The most promising polymeric biomaterials and local drug delivery.Neural regeneration research · 2026Article
- Advanced therapy medicinal product (ATMP) classification - a case study on spinal cord injury.Journal of translational medicine · 2026Review
- Phase-dependent efficacy of intravenous amniotic mesenchymal stem cells in a rat spinal cord injury model.Stem cell research & therapy · 2026Article
- Reverse translational research of transient magnetic resonance imaging hyperintensity following intracranial stem cell therapy.Stem cell research & therapy · 2025Article
- Biology of stem cell paradox: a double-edged sword-implications for cancer therapy.Cancer cell international · 2025Review
- Intramedullary Neural Stem Cell Transplantation in Spinal Cord Injury: Timing, Targets, and Techniques.Korean journal of neurotrauma · 2025Review
- Intra-Arterial Administration of Stem Cells and Exosomes for Central Nervous System Disease.International journal of molecular sciences · 2025Review
- Magnetic nanoparticles influence the biological function of mesenchymal stem cells.Scientific reports · 2025Article
- Enhancing spinal cord injury repair through PTCH1-mediated neural progenitor cell differentiation induced by ion elemental-optimized layered double hydroxides.Materials today. Bio · 2025Article
- Ultrasound-driven wireless piezoelectric hydrogel synergizes with cotransplantation of NSCs-hUCMSCs for structural and functional recovery in spinal cord injury.Materials today. Bio · 2025Article
- Personalized Stem Cell-Based Regeneration in Spinal Cord Injury Care.International journal of molecular sciences · 2025Review
- Article
- Exosome-Loaded Bioscaffolds for Spinal Cord Injuries: A Review.Stem cells international · 2025Review
- Targeting ferroptosis in spinal cord injury through stem cell therapy: mechanisms and therapeutic prospects.Frontiers in neuroscience · 2025Review
- nTMS in spinal cord injury: Current evidence, challenges and a future direction.Brain & spine · 2025Review
- Olfactory mucosal mesenchymal stem cells delivered by gelatin sponge scaffolds promote functional recovery of spinal cord injury.Frontiers in bioengineering and biotechnology · 2025Article
- The Critical Management of Spinal Cord Injury: A Narrative Review.Clinics and practice · 2024Review
- Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
There are more than one million patients worldwide suffering paralysis caused by spinal cord injury (SCI). SCI causes severe socioeconomic problems not only to the patients and their caregivers but also to society; therefore, the development of innovative treatments is crucial. Many pharmacological therapies have been attempted in an effort to reduce SCI-related damage; however, no single therapy that could dramatically improve the serious long-term sequelae of SCI has emerged. Stem cell transplantation therapy, which can ameliorate damage or regenerate neurological networks, has been proposed as a promising candidate for SCI treatment, and many basic and clinical experiments using stem cells for SCI treatment have been launched, with promising results. However, the cell transplantation methods, including cell type, dose, transplantation route, and transplantation timing, vary widely between trials, and there is no consensus regarding the most effective treatment strategy. This study reviews the current knowledge on this issue, with a special focus on the clinical trials that have used stem cells for treating SCI, and highlights the problems that remain to be solved before the widespread clinical use of stem cells can be adopted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.