Evidence map›Paper›PMID 32498414›Full record

ArticleBiomolecules2020

Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite.

Sara Ceccacci, Jana Deitersen, Matteo Mozzicafreddo, Elva Morretta, Peter Proksch, Sebastian Wesselborg, Björn Stork, Maria Chiara Monti

Abstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Targeting USP-7 by a Novel Fluorinated 5-Pyrazolyl-Urea Derivative.International journal of molecular sciences · 2023
    Article
  4. Article
  5. Phomoxanthone A Targets ATP Synthase.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sara CeccacciDept. of Pharmacy, Università di Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy.
Jana DeitersenInstitute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Matteo MozzicafreddoSchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Italy.ORCID 0000-0001-9835-8446
Elva MorrettaDept. of Pharmacy, Università di Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy.
Peter ProkschInstitute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Sebastian WesselborgInstitute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Björn StorkInstitute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Maria Chiara MontiDept. of Pharmacy, Università di Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy.ORCID 0000-0002-1337-2909

Funding

Deutsche Forschungsgemeinschaft GRK 2158Ministero dell'Istruzione, dell'Università e della Ricerca 2017FJZZRC
6 · The paper itself

Abstract

Phomoxanthone A, a bioactive xanthone dimer isolated from the endophytic fungus

Indexed as

Carbamoyl-Phosphate Synthase (Ammonia)HeLa CellsHumansMolecular Docking SimulationPhomopsisXanthonesCarbamoyl-Phosphate Synthase (Ammonia)CPS1 protein, humanphomoxanthone AXanthonesbioactive xanthonedrug affinity responsive target stabilitymolecular dockingproteomicstargeted-limited proteolysis

Identifiers

PMID32498414
PMCPMC7356042

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.