Evidence map›Paper›PMID 32498394›Full record

ArticleSensors (Basel, Switzerland)2020

Electrical Modeling of the Growth and Differentiation of Skeletal Myoblasts Cell Cultures for Tissue Engineering.

Alberto Olmo, Yaiza Yuste, Juan Alfonso Serrano, Andres Maldonado-Jacobi, Pablo Pérez, Gloria Huertas, Sheila Pereira, Alberto Yufera, Fernando de la Portilla

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Alberto OlmoInstituto de Microelectrónica de Sevilla, IMSE, CNM (CSIC, Universidad de Sevilla), Av. Américo Vespucio, sn 41092 Sevilla, Spain.ORCID 0000-0001-6388-4462
Yaiza YusteInstituto de Biomedicina de Sevilla (IBIS), Campus Hospital Universitario Virgen del Rocío, Avda. Manuel Siurot, s/n 41013, Sevilla, Spain.
Juan Alfonso SerranoInstituto de Microelectrónica de Sevilla, IMSE, CNM (CSIC, Universidad de Sevilla), Av. Américo Vespucio, sn 41092 Sevilla, Spain.ORCID 0000-0001-9881-0148
Andres Maldonado-JacobiInstituto de Microelectrónica de Sevilla, IMSE, CNM (CSIC, Universidad de Sevilla), Av. Américo Vespucio, sn 41092 Sevilla, Spain.
Pablo PérezInstituto de Microelectrónica de Sevilla, IMSE, CNM (CSIC, Universidad de Sevilla), Av. Américo Vespucio, sn 41092 Sevilla, Spain.
Gloria HuertasInstituto de Microelectrónica de Sevilla, IMSE, CNM (CSIC, Universidad de Sevilla), Av. Américo Vespucio, sn 41092 Sevilla, Spain.
Sheila PereiraInstituto de Biomedicina de Sevilla (IBIS), Campus Hospital Universitario Virgen del Rocío, Avda. Manuel Siurot, s/n 41013, Sevilla, Spain.
Alberto YuferaInstituto de Microelectrónica de Sevilla, IMSE, CNM (CSIC, Universidad de Sevilla), Av. Américo Vespucio, sn 41092 Sevilla, Spain.ORCID 0000-0002-1814-6089
Fernando de la PortillaInstituto de Biomedicina de Sevilla (IBIS), Campus Hospital Universitario Virgen del Rocío, Avda. Manuel Siurot, s/n 41013, Sevilla, Spain.
Instituto de Microelectrónica de Sevilla · ESInstituto de Biomedicina de Sevilla · ES

Funding

Ministerio de Ciencia e Innovación y Universidades (Spain), co-financed with FEDER. RTI2018-093512-B-C21
6 · The paper itself

Abstract

In tissue engineering, of utmost importance is the control of tissue formation, in order to form tissue constructs of clinical relevance. In this work, we present the use of an impedance spectroscopy technique for the real-time measurement of the dielectric properties of skeletal myoblast cell cultures. The processes involved in the growth and differentiation of these cell cultures in skeletal muscle are studied. A circuit based on the oscillation-based test technique was used, avoiding the use of high-performance circuitry or external input signals. The effect of electrical pulse stimulation applied to cell cultures was also studied. The technique proved useful for monitoring in real-time the processes of cell growth and estimating the fill factor of muscular stem cells. Impedance spectroscopy was also useful to study the real-time monitoring of cell differentiation, obtaining different oscillation amplitude levels for differentiated and undifferentiated cell cultures. Finally, an electrical model was implemented to better understand the physical properties of the cell culture and control the tissue formation process.

Indexed as

Cell Culture TechniquesElectric StimulationTissue EngineeringCell DifferentiationHumansMyoblasts, Skeletalelectrical modelingimpedance spectroscopyoscillation-based testskeletal musclestem cell differentiation

Identifiers

PMID32498394
PMCPMC7309147
OpenAlexW3033996089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.