Evidence map›Paper›PMID 32498393›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Beta-Lactam Sensitive Bacteria Can Acquire ESBL-Resistance via Conjugation after Long-Term Exposure to Lethal Antibiotic Concentration.

Pilvi Ruotsalainen, Cindy Given, Reetta Penttinen, Matti Jalasvuori

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Pilvi RuotsalainenNanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, P.O.Box 35, FI-40014 Jyväskylä, Finland.
Cindy GivenNanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, P.O.Box 35, FI-40014 Jyväskylä, Finland.
Reetta PenttinenNanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, P.O.Box 35, FI-40014 Jyväskylä, Finland.ORCID 0000-0003-2152-9889
Matti JalasvuoriNanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, P.O.Box 35, FI-40014 Jyväskylä, Finland.
University of Jyväskylä · FIUniversity of Turku · FI

Funding

Academy of Finland 252411Academy of Finland 297049Academy of Finland 322204Emil Aaltosen Säätiö MJ01Jane ja Aatos Erkon Säätiö MJ01
6 · The paper itself

Abstract

Beta-lactams are commonly used antibiotics that prevent cell-wall biosynthesis. Beta-lactam sensitive bacteria can acquire conjugative resistance elements and hence become resistant even after being exposed to lethal (above minimum inhibitory) antibiotic concentrations. Here we show that neither the length of antibiotic exposure (1 to 16 h) nor the beta-lactam type (penam or cephem) have a major impact on the rescue of sensitive bacteria. We demonstrate that an evolutionary rescue can occur between different clinically relevant bacterial species (

Indexed as

antibiotic resistanceconjugative plasmid.evolutionary rescueExtended-spectrum beta-lactamase

Identifiers

PMID32498393
PMCPMC7345503
OpenAlexW3033778151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.