ReviewAntioxidants (Basel, Switzerland)2020
Use of Melatonin in Oxidative Stress Related Neonatal Diseases.
Review in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Plant-Derived Substances for Prevention of Necrotising Enterocolitis: A Systematic Review of Animal Studies.Nutrients · 2024Pooled it
- Review
- Urinary 6-sulfatoxymelatonin as a predictive biomarker for brain injury in very preterm infants.Scientific reports · 2026Article
- Blood Melatonin in Breast Milk-Fed Preterm Infants: Longitudinal Biomonitoring to 38 Weeks' Postmenstrual Age (ProMote Study).Children (Basel, Switzerland) · 2025Article
- The Chronological Trigger: The Orchestra Between Homeobox Genes and the Circadian Clock During Development.Biology of the cell · 2025Review
- Exploring Anti-Inflammatory Treatment as Upstream Therapy in the Management of Atrial Fibrillation.Journal of clinical medicine · 2025Review
- Article
- Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway.Molecular and cellular biochemistry · 2024Article
- Melatonin's Impact on Wound Healing.Antioxidants (Basel, Switzerland) · 2024Review
- Postnatal Development of the Circadian Rhythmicity of Human Pineal Melatonin Synthesis and Secretion (Systematic Review).Children (Basel, Switzerland) · 2024Review
- Lower plasma melatonin levels in non-hypoxic premature newborns associated with neonatal pain.European journal of pediatrics · 2024Article
- Advancements in understanding the role of ferroptosis in hypoxia-associated brain injury: a narrative review.Translational pediatrics · 2024Review
- Neuroprotective effects of maternal melatonin administration in early-onset placental insufficiency and fetal growth restriction.Pediatric research · 2024Article
- Effect of Melatonin on Herpesvirus Type 1 Replication.International journal of molecular sciences · 2024Article
- Peculiarities of melatonin levels in preterm infants.Wiener klinische Wochenschrift · 2024Article
- Melatonin as a Therapy for Preterm Brain Injury: What Is the Evidence?Antioxidants (Basel, Switzerland) · 2023Review
- Chitosan-sEPDM and Melatonin-Chitosan-sEPDM Composite Membranes for Melatonin Transport and Release.Membranes · 2023Article
- The relationship of melatonin concentration in preterm infants and adverse outcomes in the late neonatal period.Biochemia medica · 2023Article
- Impact of Melatonin as a Premedication Agent in Caesarean Section on Blood Loss and Postoperative Pain Level.Anesthesiology research and practice · 2023Article
- The Emerging Roles of Ferroptosis in Neonatal Diseases.Journal of inflammation research · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species have a crucial role in the pathogenesis of perinatal diseases. Exposure to inflammation, infections, or high oxygen concentrations is frequent in preterm infants, who have high free iron levels that enhance toxic radical generation and diminish antioxidant defense. The peculiar susceptibility of newborns to oxidative stress supports the prophylactic use of melatonin in preventing or decreasing oxidative stress-mediated diseases. Melatonin, an effective direct free-radical scavenger, easily diffuses through biological membranes and exerts pleiotropic activity everywhere. Multiple investigations have assessed the effectiveness of melatonin to reduce the "oxygen radical diseases of newborn" including perinatal brain injury, sepsis, chronic lung disease (CLD), and necrotizing enterocolitis (NEC). Further studies are still awaited to test melatonin activity during perinatal period.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.