ArticleNutrients2020
Pathophysiological Mechanisms by which Heat Stress Potentially Induces Kidney Inflammation and Chronic Kidney Disease in Sugarcane Workers.
Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04985292 (Does Probiotic Supplementation Prevent Kidney Injury During Strenuous Physical Exercise?), which is not on this map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Does Probiotic Supplementation Prevent Kidney Injury During Strenuous Physical Exercise?
Who cites it
68 citing papers in PubMed, 116 citations in OpenAlex.
- Effects of race distance and probiotics intervention on kidney, muscle, and gut injury and inflammation biomarker responses during running.Journal of the International Society of Sports Nutrition · 2026Trial
- Longitudinal assessment of kidney function in migrant farm workers.Environmental research · 2021Trial
- Epidemiology, mechanisms and clinical implications of heat-related kidney disease.Nature reviews. Nephrology · 2026Review
- Article
- Investigating the Potential Mechanism of Oxymatrine in Alleviating Heat Stress Injury Based on Network Pharmacology, Molecular Docking, and In Vitro Validation.International journal of molecular sciences · 2026Article
- Impact of heatwave exposure on chronic kidney disease risk among middle-aged and older adults: evidence from the China health and retirement longitudinal study.BMC nephrology · 2026Article
- Occupational heat exposure and chronic kidney disease risk under climate warming: a retrospective cohort study of petrochemical workers with mechanistic insights.Environmental health : a global access science source · 2026Article
- Time-series analysis of the incidence trend of heat stress-related disorders in a hot and humid climate in a process industry.Scientific reports · 2026Article
- Alpha-Actinin-3 Deficiency Links Genetic Susceptibility to Renal Fibrosis: Evidence From Hemodialysis Patients and Murine Models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Heat Stress and Kidney Injury: A Growing Concern Amidst Climate Change.Kidney medicine · 2026Review
- Ad libitum drinking does not mitigate acute kidney injury risk nor elevations in markers of oxidative stress and inflammation during simulated occupational heat stress.American journal of physiology. Renal physiology · 2026Article
- Mesoamerican nephropathy as a potential contributor to chronic allograft dysfunction in tropical settings.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Oxidative Stress in Heat Stress Nephropathy: Crosstalk.Oxidative medicine and cellular longevity · 2026Review
- Longitudinal associations and interactions of heat and metal(loid) exposure with kidney outcomes in Mexican agricultural workers.Environmental research · 2025Article
- Article
- One day of environment-induced heat stress causes injury to the murine kidney.Experimental physiology · 2025Article
- The silent epidemic of CKDu: advances, challenges, and strategies for sustainable eradication-a narrative review.Clinical and experimental nephrology · 2025Review
- Biomarkers of Kidney Function and Injury Across Fire Seasons and During a Mid-Season Fire Incident in the Wildland Firefighter Exposure and Health Effect (WFFEHE) Study.American journal of industrial medicine · 2025Article
- Heat Stress Nephropathy in CKD of Uncertain Etiology Hotspots of Bargarh District Odisha, India.Kidney international reports · 2025Article
- Longitudinal Estimated GFR Trajectories Among Workers at High Risk for CKD of Unknown Etiology.Kidney international reports · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 4 countries.
Funding
Abstract
backgroundChronic kidney disease of non-traditional origin (CKDnt) is common among Mesoamerican sugarcane workers. Recurrent heat stress and dehydration is a leading hypothesis. Evidence indicate a key role of inflammation.
methodsStarting in sports and heat pathophysiology literature, we develop a theoretical framework of how strenuous work in heat could induce kidney inflammation. We describe the release of pro-inflammatory substances from a leaky gut and/or injured muscle, alone or in combination with tubular fructose and uric acid, aggravation by reduced renal blood flow and increased tubular metabolic demands. Then, we analyze longitudinal data from >800 sugarcane cutters followed across harvest and review the CKDnt literature to assess empirical support of the theoretical framework.
resultsInflammation (CRP elevation and fever) and hyperuricemia was tightly linked to kidney injury. Rehydrating with sugary liquids and NSAID intake increased the risk of kidney injury, whereas electrolyte solution consumption was protective. Hypokalemia and hypomagnesemia were associated with kidney injury. DISCUSSION: Heat stress, muscle injury, reduced renal blood flow and fructose metabolism may induce kidney inflammation, the successful resolution of which may be impaired by daily repeating pro-inflammatory triggers. We outline further descriptive, experimental and intervention studies addressing the factors identified in this study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.