Evidence map›Paper›PMID 32498097›Full record

ReviewHamostaseologie2020

Coagulopathy in COVID-19 and Its Implication for Safe and Efficacious Thromboprophylaxis.

Florian Langer, Stefan Kluge, Robert Klamroth, Johannes Oldenburg

Open access · bronzeAbstract readReview
In one paragraph

Review in Hamostaseologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 5 pooled it
2.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Guideline
  5. Guideline
  6. Trial
  7. Review
  8. Article
  9. Review
  10. Early SARS-CoV-2 infection: Platelet-neutrophil complexes and platelet function.Research and practice in thrombosis and haemostasis · 2023
    Article
  11. Article
  12. Article
  13. The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1.Journal of thrombosis and haemostasis : JTH · 2022
    Article
  14. Review
  15. A comprehensive review of vascular complications in COVID-19.Journal of thrombosis and thrombolysis · 2022
    Review
  16. Review
  17. First report from the German COVID-19 autopsy registry.The Lancet regional health. Europe · 2022
    Article
  18. Review of Case Study: Chowdhry, Moshman, and Caroll (2021). A Case of COVID-19 Related Coagulopathy Complications and Heparin Resistance.Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Florian LangerZentrum für Onkologie, II. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Stefan KlugeKlinik für Intensivmedizin, Zentrum für Anästhesiologie und Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Robert KlamrothZentrum für Gefäßmedizin, Klinik für Innere Medizin - Angiologie und Hämostaseologie, Vivantes Klinikum im Friedrichshain, Berlin, Germany.
Johannes OldenburgInstitut für Experimentelle Hämatologie und Transfusionsmedizin, Universitätsklinik Bonn, Bonn, Germany.
University Medical Center Hamburg-Eppendorf · DEKlinikum im Friedrichshain · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The novel coronavirus, SARS-CoV-2, is causing a global pandemic of life-threatening multiorgan disease, called COVID-19. Accumulating evidence indicates that patients with COVID-19 are at significant risk of thromboembolic complications, mainly affecting the venous, but also the arterial vascular system. While the risk of venous thromboembolism (VTE) appears to be higher in patients requiring intensive care unit support compared to those admitted to general wards, recent autopsy findings and data on the timing of VTE diagnosis relative to hospitalization clearly suggest that thromboembolic events also contribute to morbidity and mortality in the ambulatory setting. In addition to a severe hypercoagulable state caused by systemic inflammation and viral endotheliitis, some patients with advanced COVID-19 may develop a coagulopathy, which meets established laboratory criteria for disseminated intravascular coagulation, but is not typically associated with relevant bleeding. Similar to other medical societies, the Society of Thrombosis and Haemostasis Research has issued empirical recommendations on initiation, dosing, and duration of pharmacological VTE prophylaxis in COVID-19 patients.

Indexed as

AnticoagulantsAutopsyBetacoronavirusBlood Coagulation DisordersCase-Control StudiesChinaCoronavirus InfectionsCOVID-19Disseminated Intravascular CoagulationHeparin, Low-Molecular-WeightHospitalizationHumansPandemicsPneumonia, ViralSARS-CoV-2SurvivorsAnticoagulantsHeparin, Low-Molecular-Weight

Identifiers

PMID32498097
PMCPMC7416221
OpenAlexW3033343884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.