Evidence map›Paper›PMID 32498089›Full record

ArticleThe Journal of clinical endocrinology and metabolism2020

Sex Differences in 11-Oxygenated Androgen Patterns Across Adulthood.

Angela Davio, Helen Woolcock, Aya T Nanba, Juilee Rege, Patrick O'Day, Jianwei Ren, Lili Zhao, Hiroki Ebina, Richard Auchus, William E Rainey and 1 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 74 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival.Annals of clinical and translational neurology · 2026
    Article
  5. Review
  6. Article
  7. Observational
  8. Article
  9. Human Gonads Do Not Contribute to the Circulating Pool of 11-Oxygenated Androgens.The Journal of clinical endocrinology and metabolism · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Compensatory mechanisms that maintain androgen production in mice lacking key androgen biosynthetic enzymes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Hormones and Aging: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Angela DavioDivision of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, US.
Helen WoolcockDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, US.
Aya T NanbaDivision of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, US.
Juilee RegeDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, US.
Patrick O'DayDivision of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, US.
Jianwei RenDivision of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, US.
Lili ZhaoSchool of Public Health, University of Michigan, Ann Arbor, MI, US.
Hiroki EbinaDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, US.
Richard AuchusDivision of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, US.
William E RaineyDivision of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, US.
Adina F TurcuDivision of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, US.
University of Michigan · US

Funding

Molecular Mechanisms of AdrenarcheR01DK069950 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAINEY, WILLIAM E · 2005 to 2019
$4.4M
The contemporary endocrinology of congenital adrenal hyperplasiaK08DK109116 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TURCU, ADINA F · 2016 to 2020
$832k
NIDDK NIH HHS K08 DK109116NIDDK NIH HHS R01 DK069950
6 · The paper itself

Abstract

contextThe gonads are the major source of sex steroids during reproductive ages. The gonadal function declines abruptly in women and gradually in men. The adrenals produce 11-oxygenated androgens (11-oxyandrogens), which start rising during adrenarche. Following menopause, 11-oxyandrogens levels remain similar to reproductive ages.

objectiveTo compare the circulating 11-oxyandrogen concentrations in men and women across adult ages.

methodsWe used mass spectrometry to measure testosterone (T), androstenedione (A4), 11β-hydroxytestosterone (11OHT), 11-ketotestosterone (11KT), 11β-hydroxyandrostenedione (11OHA4), 11-ketoandrostenedione (11KA4), cortisol, and cortisone in morning sera obtained from adults in outpatient setting. We performed double immunofluorescence of 3β-hydroxysteroid dehydrogenase type 2 and cytochrome b5 in adrenal tissue from 19 men, age 23-78 years.

resultsWe included 590 patients (319 men), aged 18 to 97 years, and 84% white. 11KT and 11KA4 were stable across ages in women, but they declined in men (0.21 and 0.06 ng/dL/year, respectively; P < 0.05). 11OHA4 and 11OHT increased modestly with age in women (0.6 and 0.09 ng/dL/year, respectively; P < 0.01), and both remained stable across ages in men. As body mass index (BMI) increased, 11KA4 decreased in women, and 11KT increased in men, both suggesting higher 17β-hydroxysteroid dehydrogenase activity in obese individuals. A4 and T declined with age and A4 with BMI in both sexes; T declined with BMI in men. Adrenal androgenic enzyme expressions in aging men were similar to those observed in women.

conclusionsIn contrast with traditional androgens, the production of 11OHA4 and 11OHT is sustained with aging in both sexes. The bioactive androgen 11KT declines in aging men but not in women.

Indexed as

AdolescentAdultAgedAged, 80 and overAgingAndrogensAndrostenedioneCohort StudiesFemaleHumansHydroxytestosteronesMaleMiddle AgedSex FactorsTestosteroneYoung Adult11-hydroxyandrostenedione11-hydroxytestosterone11-ketotestosteroneAndrogensAndrostenedioneHydroxytestosteronesTestosterone11-ketotestosterone11-oxyandrogensadrenaladrenal cortexagingandrogens

Identifiers

PMID32498089
PMCPMC7340191
OpenAlexW3034089088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.