Evidence map›Paper›PMID 32498034›Full record

ArticleMultiple sclerosis and related disorders2020

Restless legs syndrome, sleep quality, and perceived cognitive impairment in adults with multiple sclerosis.

Katie L J Cederberg, Brenda Jeng, Jeffer E Sasaki, Robert W Motl

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis and related disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  4. Nabiximols improves sleep architecture in multiple sclerosis: A prospective polysomnographic study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Katie L J CederbergDepartment of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL USA. Electronic address: kcederb@uab.edu.
Brenda JengDepartment of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL USA.
Jeffer E SasakiDepartment of Sport Sciences, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
Robert W MotlDepartment of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL USA.
University of Alabama at Birmingham · USUniversidade Federal do Triângulo Mineiro · BR

Funding

Restless legs syndrome and physical activity in adults with multiple sclerosisF31HD097903 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CEDERBERG, KATIE L.J. · 2019 to 2020
$60k
NICHD NIH HHS F31 HD097903
6 · The paper itself

Abstract

backgroundRestless Legs Syndrome (RLS) is a prominent sleep disorder that often worsens sleep quality and perhaps cognitive function in adults with multiple sclerosis (MS). The present study examined the relationships among RLS prevalence and severity, sleep quality, and perceived cognitive impairment in adults with MS.

methodsParticipants (N=275) completed the Cambridge-Hopkins Restless Legs Syndrome Questionnaire, the International Restless Legs Syndrome Study Group (IRLS) Scale, the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ), the Pittsburgh Sleep Quality Index (PSQI), the Patient Determined Disease Steps (PDDS), and a demographic and clinical characteristics questionnaire.

resultsPersons with MS who had RLS (i.e., MS+RLS; n=74) reported significantly worse perceived cognitive impairment compared with those who did not have RLS (n=201; p=0.015). Bivariate correlation analyses within the MS+RLS group indicated that greater RLS severity was significantly associated with more severe perceived cognitive impairment (r=0.274) and sleep quality (r=0.380), and worse perceived cognitive impairment was significantly associated with worse sleep quality (r=0.438). Linear, step-wise regression analyses indicated that RLS severity significantly predicted perceived cognitive impairment (β=0.274), but the inclusion of sleep quality (β=0.391) accounted for the relationship between RLS severity and perceived cognitive impairment (β=0.126).

conclusionsOur results suggest that sleep impairment may be an intermediary factor in the association between RLS severity and cognitive impairment in persons with MS who present with RLS. The diagnosis and treatment of RLS symptoms and other effectors of sleep quality could improve neuropsychological consequences of MS.

Indexed as

Cognitive DysfunctionMultiple SclerosisRestless Legs SyndromeSleep Wake DisordersAdultHumansSeverity of Illness IndexSleepSurveys and QuestionnairesCognitive functionMultiple sclerosisRestless Legs SyndromeSleep quality

Identifiers

PMID32498034
PMCPMC7363523
OpenAlexW3027346768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.