Evidence map›Paper›PMID 32497793›Full record

ArticleCellular and molecular gastroenterology and hepatology2021

A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and Autophagy.

Yong Hua Sheng, Rabina Giri, Julie Davies, Veronika Schreiber, Saleh Alabbas, Ramya Movva, Yaowu He, Andy Wu, John Hooper, Brett McWhinney and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular gastroenterology and hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. CD8Journal of translational medicine · 2024
    Review
  3. Uphill battle: Innovation of thiopurine therapy in global inflammatory bowel disease care.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Review
  4. Review
  5. Review
  6. [Ulcerative colitis-associated carcinogenesis : An update].Pathologie (Heidelberg, Germany) · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Yong Hua ShengInflammatory Bowel Diseases Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland; Inflammatory Disease Biology and Therapeutics Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland.
Rabina GiriInflammatory Bowel Diseases Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland.
Julie DaviesInflammatory Bowel Diseases Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland.
Veronika SchreiberInflammatory Bowel Diseases Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland.
Saleh AlabbasInflammatory Bowel Diseases Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland.
Ramya MovvaInflammatory Bowel Diseases Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland.
Yaowu HeCancer Biology Group, Mater Research Institute-University of Queensland, Woolloongabba, Queensland.
Andy WuBones and Immunology Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland.
John HooperCancer Biology Group, Mater Research Institute-University of Queensland, Woolloongabba, Queensland.
Brett McWhinneyQueensland Pathology Services, Herston.
Iulia OanceaSchool of Clinical Medicine, Faculty of Medicine, University of Queensland.
Gregor KijankaImmune Profiling & Cancer Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland.
Sumaira HasnainInflammatory Disease Biology and Therapeutics Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland.
Andrew J LuckeARC Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
David P FairlieARC Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Michael A McGuckinFaculty of Medicine Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria.
Timothy H FlorinInflammatory Bowel Diseases Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland. Electronic address: t.florin@uq.edu.au.
Jakob BegunInflammatory Bowel Diseases Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland; Inflammatory Disease Biology and Therapeutics Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Queensland; School of Clinical Medicine, Faculty of Medicine, University of Queensland. Electronic address: jakob.begun@mater.uq.edu.au.
Translational Research Institute · AUThe University of Queensland · AUQueensland Health · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsChronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD). Abnormal Wnt/β-catenin signalling is characteristic of >90% of colorectal cancers. Immunosuppression by thiopurines is via Rac1 GTPase, which also affects Wnt/β-catenin signalling. Autophagy is implicated in colonic tumors, and topical delivery of the thiopurine thioguanine (TG) is known to alleviate colitis and augment autophagy. This study investigated the effects of TG in a murine model of CAC and potential mechanisms.

methodsColonic dysplasia was induced by exposure to azoxymethane (AOM) and dextran sodium sulfate (DSS) in wild-type (WT) mice and mice harboring intestinal epithelial cell-specific deletion of autophagy related 7 gene (Atg7

resultsTG ameliorated DSS colitis in wild-type but not Atg7

conclusionsOur findings provide evidence for a new mechanism that could be exploited to improve CAC chemoprophylactic approaches.

Indexed as

Administration, RectalAnimalsAutophagyAutophagy-Related Protein 7Azoxymethanebeta CateninCaco-2 CellsColitisColitis-Associated NeoplasmsColonDextran SulfateGene Knockdown TechniquesHCT116 CellsHumansIntestinal MucosaMercaptopurineAutophagy-Related Protein 7Azoxymethanebeta CateninDextran SulfateMercaptopurineNeuropeptidesrac1 GTP-Binding ProteinRac1 protein, mouseThioguanineAutophagyColon CancerThioguanineβ-Catenin

Identifiers

PMID32497793
PMCPMC7593585
OpenAlexW3033514486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.