Evidence map›Paper›PMID 32497785›Full record

ArticleNeuroImage2020

A Symmetric Prior for the Regularisation of Elastic Deformations: Improved anatomical plausibility in nonlinear image registration.

Frederik J Lange, John Ashburner, Stephen M Smith, Jesper L R Andersson

Abstract read
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Hierarchical modelling of crossing fibres in the white matter.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  4. MMORF-FSL's MultiMOdal Registration Framework.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Frederik J LangeCentre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK. Electronic address: frederik.lange@dtc.ox.ac.uk.
John AshburnerWellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London, WC1N 3BG, UK. Electronic address: j.ashburner@ucl.ac.uk.
Stephen M SmithCentre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK. Electronic address: steve@fmrib.ox.ac.uk.
Jesper L R AnderssonCentre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK. Electronic address: jesper.andersson@ndcn.ox.ac.uk.

Funding

MAPPING THE HUMAN CONNECTOME DURING TYPICAL AGINGU01AG052564 · NIA · WASHINGTON UNIVERSITY · PI SALAT, DAVID H, TERPSTRA, MELISSA J · 2016 to 2020
$18.9M
Mapping the Human Connectome During Typical DevelopmentU01MH109589 · NIMH · WASHINGTON UNIVERSITY · PI BARCH, DEANNA, BOOKHEIMER, SUSAN Y · 2016 to 2019
$17.1M
Medical Research CouncilNIA NIH HHS U01 AG052564NIMH NIH HHS U01 MH109589Wellcome Trust 098369Wellcome Trust 098369/Z/12/ZWellcome Trust 203139Wellcome Trust 203139/Z/16/ZWellcome Trust 203147/Z/16/Z
6 · The paper itself

Abstract

Nonlinear registration is critical to many aspects of Neuroimaging research. It facilitates averaging and comparisons across multiple subjects, as well as reporting of data in a common anatomical frame of reference. It is, however, a fundamentally ill-posed problem, with many possible solutions which minimise a given dissimilarity metric equally well. We present a regularisation method capable of selectively driving solutions towards those which would be considered anatomically plausible by penalising unlikely lineal, areal and volumetric deformations. This penalty is symmetric in the sense that geometric expansions and contractions are penalised equally, which encourages inverse-consistency. We demonstrate that this method is able to significantly reduce local volume changes and shape distortions compared to state-of-the-art elastic (FNIRT) and plastic (ANTs) registration frameworks. Crucially, this is achieved whilst simultaneously matching or exceeding the registration quality of these methods, as measured by overlap scores of labelled cortical regions. Extensive leveraging of GPU parallelisation has allowed us to solve this highly computationally intensive optimisation problem while maintaining reasonable run times of under half an hour.

Indexed as

AlgorithmsBrainHumansImage Processing, Computer-AssistedNeuroimagingAnatomical plausibilityDiffeomorphismElastic deformationGPU ParallelisationNonlinear registrationRegularisation

Identifiers

PMID32497785
PMCPMC7610794

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.