ArticleHippocampus2020
Longitudinal development of hippocampal subregions from early- to mid-childhood.
Article in Hippocampus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of the relation between hippocampal volume and memory ability in typically developing children and adolescents.Hippocampus · 2022Pooled it
- Trajectories of hippocampal subregion development in the first years of life and their association with school-aged episodic memory outcomes.bioRxiv : the preprint server for biology · 2026Article
- A Longitudinal Study of Children's Hippocampal Development: Investigating Maternal Physical Activity, Depression, and Education.Developmental neurobiology · 2026Article
- Age-related volumetric differences of hippocampal subfields in the developing brain: a retrospective MRI study.Brain structure & function · 2026Article
- Chronic hypoxia reshapes the brain: subregional volume reductions of the hippocampus and amygdala contrasts with behavioral resilience in long-term high-altitude migrants.Frontiers in neuroscience · 2026Article
- Associations Between Experience of Typical Variations in Stressors and Hippocampal Structure and Functional Connectivity in Childhood.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025Article
- Relations between 24-h movement behaviors, declarative memory, and hippocampal volume in early childhood.Scientific reports · 2025Article
- Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure.Journal of neurodevelopmental disorders · 2025Article
- Structural Neuroimaging of Hippocampus and Amygdala Subregions in Posttraumatic Stress Disorder: A Scoping Review.Biological psychiatry global open science · 2024Article
- Hippocampus substructure segmentation using morphological vision transformer learning.Physics in medicine and biology · 2023Article
- Extended trajectory of spatial memory errors in typical and atypical development: The role of binding and precision.Hippocampus · 2023Article
- Household socioeconomic status relates to specific hippocampal subfield volumes across development.Hippocampus · 2023Article
- Hippocampal anterior- posterior shift in childhood and adolescence.Progress in neurobiology · 2023Article
- Volumetric development of hippocampal subfields and hippocampal white matter connectivity: Relationship with episodic memory.Developmental psychobiology · 2022Article
- The fornix supports episodic memory during childhood.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Children show adult-like hippocampal pattern similarity for familiar but not novel events.Brain research · 2022Article
- Chinese Color Nest Project : An accelerated longitudinal brain-mind cohort.Developmental cognitive neuroscience · 2021Review
- Understanding relational binding in early childhood: Interacting effects of overlap and delay.Journal of experimental child psychology · 2021Article
- Modeling longitudinal changes in hippocampal subfields and relations with memory from early- to mid-childhood.Developmental cognitive neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Early childhood is characterized by vast changes in behaviors supported by the hippocampus and an increased susceptibility of the hippocampus to environmental influences. Thus, it is an important time to investigate the development of the hippocampus. Existing research suggests subregions of the hippocampus (i.e., head, body, tail) have dissociable functions and that the relations between subregions and cognitive abilities vary across development. However, longitudinal research examining age-related changes in subregions in humans, particularly during early childhood (i.e., 4-6 years), is limited. Using a large sample of 184 healthy 4- to 8-year-old children, the present study is the first to characterize developmental changes in hippocampal subregion volume from early- to mid-childhood. Results reveal differential developmental trajectories in hippocampal head, body, and tail during this period. Specifically, head volume showed a quadratic pattern of change, and both body and tail showed linear increases, resulting in a pattern of cubic change for total hippocampal volume. Further, main effects of sex on hippocampal volume (males > females) and hemispheric differences in developmental trajectories were observed. These findings provide an improved understanding of the development of the hippocampus and have important implications for research investigating a range of cognitive abilities and behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.