Evidence map›Paper›PMID 32497334›Full record

ArticleJournal of medical virology2021

A missing link between SARS-CoV-2 and the eye?: ACE2 expression on the ocular surface.

Rafael S Grajewski, Alexander C Rokohl, Martina Becker, Felix Dewald, Clara Lehmann, Gerd Fätkenheuer, Claus Cursiefen, Florian Klein, Ludwig M Heindl

Abstract readLetterComment
In one paragraph

Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. The impact of a rub and rinse regimen on removal of human coronaviruses from contemporary contact lens materials.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2022
    Article
  5. Review
  6. Detection of SARS-CoV-2-RNA in post-mortem samples of human eyes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Malignancy going viral: ACE2 and TMPRSS2 expression in conjunctival neoplastic diseases.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2021
    Article
  16. Article
  17. Review
  18. What is the significance of the conjunctiva as a potential transmission route for SARS-CoV-2 infections?Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021
    Review
  19. Article
  20. More than loss of taste and smell: burning watering eyes in coronavirus disease 2019.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020
    Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Rafael S GrajewskiDepartment of Ophthalmology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-6489-2982
Alexander C RokohlDepartment of Ophthalmology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Martina BeckerDepartment of Ophthalmology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Felix DewaldLaboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Clara LehmannDepartment of Internal Medicine I, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Gerd FätkenheuerDepartment of Internal Medicine I, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Claus CursiefenDepartment of Ophthalmology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Florian KleinLaboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Ludwig M HeindlDepartment of Ophthalmology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angiotensin-Converting Enzyme 2COVID-19SARS-CoV-2ConjunctivaHumansReceptors, VirusAngiotensin-Converting Enzyme 2Receptors, Virus

Identifiers

PMID32497334
PMCPMC7300893

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.