Evidence map›Paper›PMID 32497090›Full record

SynthesisPloS one2020

Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review.

Vinayak Smith, Densearn Seo, Ritesh Warty, Olivia Payne, Mohamed Salih, Ken Lee Chin, Richard Ofori-Asenso, Sathya Krishnan, Fabricio da Silva Costa, Beverley Vollenhoven and 1 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 17 syntheses or guidelines pooled it.

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  3. Consequences and implications of the coronavirus disease (COVID-19) on pregnancy and newborns: A comprehensive systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022
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  7. Clinical and Obstetric Aspects of Pregnant Women with COVID-19: A Systematic Review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2021
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  11. Vertical Transmission of SARS-CoV-2: A Systematic Review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2021
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  15. Is there any potential management against COVID-19? A systematic review and meta-analysis.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020
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75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vinayak SmithDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-6099-3671
Densearn SeoSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-9125-043X
Ritesh WartyDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.
Olivia PayneFetal Monitoring Unit, Monash Medical Centre, Monash Health, Clayton, Victoria, Australia.
Mohamed SalihFetal Monitoring Unit, Monash Medical Centre, Monash Health, Clayton, Victoria, Australia.
Ken Lee ChinSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Richard Ofori-AsensoDepartment of Pharmacy, University of Copenhagen, København, Denmark.
Sathya KrishnanNewborn Services, Western Health, Sunshine, Victoria, Australia.
Fabricio da Silva CostaDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.
Beverley VollenhovenDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.
Euan WallaceDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCOVID-19 has created an extraordinary global health crisis. However, with limited understanding of the effects of COVID-19 during pregnancy, clinicians and patients are forced to make uninformed decisions.

objectivesTo systematically evaluate the literature and report the maternal and neonatal outcomes associated with COVID-19. SEARCH STRATEGY: PubMed, MEDLINE, and EMBASE were searched from November 1st, 2019 and March 28th, 2020. SELECTION CRITERIA: Primary studies, reported in English, investigating COVID-19-positive pregnant women and reporting their pregnancy and neonatal outcomes. DATA COLLECTION AND ANALYSIS: Data in relation to clinical presentation, investigation were maternal and neonatal outcomes were extracted and analysed using summary statistics. Hypothesis testing was performed to examine differences in time-to-delivery. Study quality was assessed using the ICROMS tool. MAIN

resultsOf 73 identified articles, nine were eligible for inclusion (n = 92). 67.4% (62/92) of women were symptomatic at presentation. RT-PCR was inferior to CT-based diagnosis in 31.7% (26/79) of cases. Maternal mortality rate was 0% and only one patient required intensive care and ventilation. 63.8% (30/47) had preterm births, 61.1% (11/18) fetal distress and 80% (40/50) a Caesarean section. 76.92% (11/13) of neonates required NICU admission and 42.8% (40/50) had a low birth weight. There was one indeterminate case of potential vertical transmission. Mean time-to-delivery was 4.3±3.08 days (n = 12) with no difference in outcomes (p>0.05).

conclusionsCOVID-19-positive pregnant women present with fewer symptoms than the general population and may be RT-PCR negative despite having signs of viral pneumonia. The incidence of preterm births, low birth weight, C-section, NICU admission appear higher than the general population.

Indexed as

BetacoronavirusCesarean SectionClinical Laboratory TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingFemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalPandemicsPneumonia, ViralPregnancyPregnancy Complications, InfectiousPregnancy OutcomePremature Birth

Identifiers

PMID32497090
PMCPMC7272020

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.