ArticlePLoS genetics2020
An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene conversion and transposons.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Multi-omics analysis identifies loci associated with pyrethroid resistance across sister species in the Anopheles gambiae species complex.BMC genomics · 2026Article
- Signature of resistance gene evolution and pyrethroid resistance escalation in the major malaria vector Anopheles funestus across Kenyan malaria-endemic regions separated by the Rift Valley.Infectious diseases of poverty · 2026Article
- Genomic signatures of selection inbioRxiv : the preprint server for biology · 2026Article
- Identification of malaria hotspots in southwestern Benin through spatial joint modelling of malaria incidence and vector abundance.Malaria journal · 2026Article
- Soft Selective Sweeps Predominate in the Yellow Fever Mosquito Aedes aegypti.Molecular biology and evolution · 2026Article
- The genomics of insecticide resistance in Anopheles funestus: insights from a large bed-net trial.BMC genomics · 2026Article
- Optimizing insecticide deployment strategies to delay quantitative resistance in mosquito populations.Journal of mathematical biology · 2026Article
- Chlorfenapyr bednets effectively overcome pyrethroid resistance escalation in highly resistant Anopheles malaria vectors in Uganda.Scientific reports · 2026Article
- Distinct Genetic Footprint of Adaptation Observed WithinResearch and reports in tropical medicine · 2026Article
- PoolSeq Genome-Wide Association Studies and Microbial Signature Analyses Identify Novel Candidates Associated With Pyrethroid Resistance Evolution in Anopheles funestus in Cameroon.Molecular ecology · 2026Article
- Spatial Heterogeneity ofJournal of parasitology research · 2026Review
- Genetic isolation drives divergent insecticide resistance between coastal and western Kenya Anopheles funestus populations.Scientific reports · 2025Article
- Genomic Drivers of Pyrethroid Resistance Escalation in the Malaria Vector Anopheles funestus Across Africa.Molecular biology and evolution · 2025Article
- Characterizing the escalation of pyrethroid resistance and its impact on bed nets efficacy alongside molecular basis in Anopheles funestus from Cameroon.Malaria journal · 2025Article
- The duplicated cytochrome P450 CYP6P9a/b confers cross-resistance to a mitochondrial complex I inhibitor in the African malaria vector Anopheles funestus.BMC genomics · 2025Article
- Impact of Omics Studies on Understanding Insecticide Resistance Mechanisms in Sub-Saharan Malaria Vectors: A Systematic Review.Journal of arthropod-borne diseases · 2025Review
- An atlas of positive selection in the genomes of major malaria vectors.bioRxiv : the preprint server for biology · 2025Article
- Signatures of soft selective sweeps predominate in the yellow fever mosquitobioRxiv : the preprint server for biology · 2025Article
- Evidence of microbiome contribution to the escalation of pyrethroid resistance in the major malaria vectors Anopheles gambiae s.s. and Anopheles funestus s.s.BMC microbiology · 2025Article
- Signatures of selection and mechanisms of insecticide resistance in UgandanbioRxiv : the preprint server for biology · 2025Article
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Authors and funding
8 authors.
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Abstract
Insecticide resistance in malaria vectors threatens to reverse recent gains in malaria control. Deciphering patterns of gene flow and resistance evolution in malaria vectors is crucial to improving control strategies and preventing malaria resurgence. A genome-wide survey of Anopheles funestus genetic diversity Africa-wide revealed evidences of a major division between southern Africa and elsewhere, associated with different population histories. Three genomic regions exhibited strong signatures of selective sweeps, each spanning major resistance loci (CYP6P9a/b, GSTe2 and CYP9K1). However, a sharp regional contrast was observed between populations correlating with gene flow barriers. Signatures of complex molecular evolution of resistance were detected with evidence of copy number variation, transposon insertion and a gene conversion between CYP6P9a/b paralog genes. Temporal analyses of samples before and after bed net scale up suggest that these genomic changes are driven by this control intervention. Multiple independent selective sweeps at the same locus in different parts of Africa suggests that local evolution of resistance in malaria vectors may be a greater threat than trans-regional spread of resistance haplotypes.
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