Evidence map›Paper›PMID 32497004›Full record

ArticleeLife2020

Circuits that encode and guide alcohol-associated preference.

Kristin M Scaplen, Mustafa Talay, Kavin M Nunez, Sarah Salamon, Amanda G Waterman, Sydney Gang, Sophia L Song, Gilad Barnea, Karla R Kaun

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Trial
  2. Article
  3. Hunger Recruits a Parallel Circuit Encoding Alcohol Reward.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Science signaling · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Learning & memory (Cold Spring Harbor, N.Y.) · 2024
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristin M ScaplenDepartment of Neuroscience, Brown University, Providence, United States.ORCID https://orcid.org/0000-0001-7493-1420
Mustafa TalayDepartment of Neuroscience, Brown University, Providence, United States.
Kavin M NunezDepartment of Molecular Pharmacology and Physiology, Brown University, Providence, United States.
Sarah SalamonDepartment of Pharmacology, University of Cologne, Cologne, Germany.
Amanda G WatermanDepartment of Neuroscience, Brown University, Providence, United States.
Sydney GangDepartment of Biochemistry, Brown University, Providence, United States.
Sophia L SongDepartment of Neuroscience, Brown University, Providence, United States.
Gilad BarneaDepartment of Neuroscience, Brown University, Providence, United States.ORCID https://orcid.org/0000-0001-6842-3454
Karla R KaunDepartment of Neuroscience, Brown University, Providence, United States.ORCID https://orcid.org/0000-0002-8756-9528

Funding

The neural basis of sequential control in human and non-human primatesP20GM103645 · NIGMS · BROWN UNIVERSITY · PI SANES, JEROME N · 2013 to 2022
$22.9M
Notch-dependent microcircuit regulaton of alcohol reward memoryR01AA024434 · NIAAA · BROWN UNIVERSITY · PI KAUN, KARLA R. · 2016 to 2025
$3.9M
The neural circuits underlying gustatory perception in fliesR01DC017146 · NIDCD · BROWN UNIVERSITY · PI BARNEA, GILAD · 2018 to 2022
$2.0M
Functional mapping of mammalian neural circuitsR01MH105368 · NIMH · BROWN UNIVERSITY · PI BARNEA, GILAD · 2014 to 2017
$1.3M
Binational Science Foundation 2015005NIAAA NIH HHS R01 AA024434NIDCD NIH HHS R01 DC017146NIGMS NIH HHS P20 GM103645NIMH NIH HHS R01 MH105368Rhode Island Foundation Medical Research Fund 20144133
6 · The paper itself

Abstract

A powerful feature of adaptive memory is its inherent flexibility. Alcohol and other addictive substances can remold neural circuits important for memory to reduce this flexibility. However, the mechanism through which pertinent circuits are selected and shaped remains unclear. We show that circuits required for alcohol-associated preference shift from population level dopaminergic activation to select dopamine neurons that predict behavioral choice in

Indexed as

Dopaminergic NeuronsEthanolMemoryAnimalsDopamineDrosophila melanogasterFemaleMaleMushroom BodiesNerve NetRewardSynapsesDopamineEthanolalcoholD. melanogasterdopamineDrosophilafan-shaped bodymemorymushroom bodyneuroscience

Identifiers

PMID32497004
PMCPMC7272191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.