Evidence map›Paper›PMID 32496878›Full record

ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Comparison of Thromboelastography and Conventional Coagulation Tests in Patients With Severe Liver Disease.

Patryck Lloyd-Donald, Abhinav Vasudevan, Peter Angus, Paul Gow, Johan Mårtensson, Neil Glassford, Glenn M Eastwood, Graeme K Hart, Daryl Jones, Laurence Weinberg and 1 more

Open access · goldAbstract read
In one paragraph

Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  12. Clinical Application of Thromboelastography in Acute Ischemic Stroke.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Patryck Lloyd-DonaldDepartment of Intensive Care, Austin Health, Heidelberg, Melbourne, Australia.ORCID https://orcid.org/0000-0003-0260-6228
Abhinav VasudevanDepartment of Gastroenterology and Hepatology, Austin Health, Heidelberg, Melbourne, Australia.
Peter AngusDepartment of Gastroenterology and Hepatology, Austin Health, Heidelberg, Melbourne, Australia.
Paul GowDepartment of Gastroenterology and Hepatology, Austin Health, Heidelberg, Melbourne, Australia.
Johan MårtenssonDepartment of Intensive Care, Austin Health, Heidelberg, Melbourne, Australia.ORCID https://orcid.org/0000-0001-8739-7896
Neil GlassfordDepartment of Intensive Care, Austin Health, Heidelberg, Melbourne, Australia.
Glenn M EastwoodDepartment of Intensive Care, Austin Health, Heidelberg, Melbourne, Australia.
Graeme K HartDepartment of Intensive Care, Austin Health, Heidelberg, Melbourne, Australia.
Daryl JonesDepartment of Intensive Care, Austin Health, Heidelberg, Melbourne, Australia.
Laurence WeinbergDepartment of Anaesthesia, Austin Health, Heidelberg, Melbourne, Australia.
Rinaldo BellomoDepartment of Intensive Care, Austin Health, Heidelberg, Melbourne, Australia.
Austin Health · AUKarolinska University Hospital · SEMelbourne Health · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThromboelastography (TEG) may provide rapid and clinically important coagulation information in acutely ill patients with chronic liver disease (CLD). Our objective was to describe the relationship between TEG and conventional coagulation tests (CCTs), which has not been previously explored in this population.

methodsIn acutely ill patients with severe CLD (Child-Pugh score > 9, category C), we conducted a prospective observational study investigating coagulation assessment as measured by both CCTs and TEG. We used quantile regression to explore 30 associations between TEG parameters and corresponding CCTs. We compared TEG and CCT measures of coagulation initiation, clot formation, clot strength, and fibrinolysis.

resultsWe studied 34 patients on a total of 109 occasions. We observed inconsistent associations between TEG and CCT measures of coagulation initiation: TEG (citrated kaolin [CK] assay) standard reaction time and international normalized ratio:

conclusionsIn acutely ill patients with CLD, there are strong and consistent associations between TEG measures of clot formation and clot strength and conventional fibrinogen levels. There are weak and/or inconsistent associations between TEG and all other conventional measures of coagulation.

Indexed as

AgedBlood Coagulation TestsFemaleHumansLiver DiseasesMaleMiddle AgedProspective StudiesThrombelastographycoagulationcoagulopathydiagnosisthrombosis

Identifiers

PMID32496878
PMCPMC7427018
OpenAlexW3033863642

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.