Evidence map›Paper›PMID 32496847›Full record

ReviewMolecular pain

Role of fragile X mental retardation protein in chronic pain.

Xiangyang Mei, Yixin Yang, Jinsong Zhao, Yongjie Wang, QiLiang Chen, Xiang Qian, Xiangyao Li, Zhiying Feng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Xiangyang MeiDepartment of Pain Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.ORCID 0000-0001-9576-932X
Yixin YangDepartment of Pain Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jinsong ZhaoDepartment of Pain Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yongjie WangInstitute of Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
QiLiang ChenDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford Health Care, Stanford University, Stanford, CA, USA.
Xiang QianDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford Health Care, Stanford University, Stanford, CA, USA.
Xiangyao LiInstitute of Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.ORCID 0000-0002-4793-0550
Zhiying FengDepartment of Pain Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.ORCID 0000-0003-0962-9449
First Affiliated Hospital Zhejiang University · CNStanford Health Care · USZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pain has detrimental effects on one's quality of life. However, its treatment options are very limited, and its underlying pathogenesis remains unclear. Recent research has suggested that fragile X mental retardation protein is involved in the development of chronic pain, making it a potential target for prevention and treatment. The current review of literature will examine the function of fragile X mental retardation protein and its associated pathways, through which we hope to gain insight into how fragile X mental retardation protein may contribute to nociceptive sensitization and chronic pain.

Indexed as

AnimalsChronic PainFragile X Messenger Ribonucleoprotein 1HumansIon ChannelsNeuronsSignal TransductionTOR Serine-Threonine KinasesFragile X Messenger Ribonucleoprotein 1Ion ChannelsTOR Serine-Threonine Kinaseschronic painFragile X mental retardation proteinion channelsmGluRsmTOR

Identifiers

PMID32496847
PMCPMC7273537
OpenAlexW3033049885

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.