ArticleThe Journal of nutrition2020
Caffeinated Coffee and Tea Consumption, Genetic Variation and Cognitive Function in the UK Biobank.
Article in The Journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review.Psychological medicine · 2021Pooled it
- Exploring the impact of coffee consumption and caffeine intake on cognitive performance in older adults: a comprehensive analysis using NHANES data and gene correlation analysis.Nutrition journal · 2025Article
- Habitual caffeine intake, genetics and cognitive performance.Journal of psychopharmacology (Oxford, England) · 2025Article
- Moderate tea consumption and dementia-related neuroimaging markers.Frontiers in neurology · 2025Article
- Association between coffee and tea consumption and the risk of dementia in individuals with hypertension: a prospective cohort study.Scientific reports · 2024Article
- Diet Pattern Analysis in Alzheimer's Disease Implicates Gender Differences in Folate-B12-Homocysteine Axis on Cognitive Outcomes.Nutrients · 2024Article
- The Relationship between Beverages Consumption and Cognitive Impairment in Middle-Aged and Elderly Chinese Population.Nutrients · 2023Article
- Association of Coffee and Tea Consumption with the Risk of Asthma: A Prospective Cohort Study from the UK Biobank.Nutrients · 2022Article
- Medical conditions associated with coffee consumption: Disease-trajectory and comorbidity network analyses of a prospective cohort study in UK Biobank.The American journal of clinical nutrition · 2022Article
- Neuroprotective Effect of Caffeine in Alzheimer's Disease.Molecules (Basel, Switzerland) · 2022Review
- Caffeine Consumption and Dementia: Are Lewy Bodies the Link?Annals of neurology · 2022Article
- Review
- Time to Recover From Daily Caffeine Intake.Frontiers in nutrition · 2021Article
- Tea and coffee consumption, cognitive impairment and prognosis in older inhabitants.EXCLI journal · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundCoffee and tea are the major contributors of caffeine in the diet. Evidence points to the premise that caffeine may benefit cognition.
objectiveWe examined the associations of habitual regular coffee or tea and caffeine intake with cognitive function whilst additionally accounting for genetic variation in caffeine metabolism.
methodsWe included white participants aged 37-73 y from the UK Biobank who provided biological samples and completed touchscreen questionnaires regarding sociodemographic factors, medical history, lifestyle, and diet. Habitual caffeine-containing coffee and tea intake was self-reported in cups/day and used to estimate caffeine intake. Between 97,369 and 445,786 participants with data also completed ≥1 of 7 self-administered cognitive functioning tests using a touchscreen system (2006-2010) or on home computers (2014). Multivariable regressions were used to examine the association between coffee, tea, or caffeine intake and cognition test scores. We also tested interactions between coffee, tea, or caffeine intake and a genetic-based caffeine-metabolism score (CMS) on cognitive function.
resultsAfter multivariable adjustment, reaction time, Pairs Matching, Trail Making test B, and symbol digit substitution, performance significantly decreased with consumption of 1 or more cups of coffee (all tests P-trend < 0.0001). Tea consumption was associated with poor performance on all tests (P-trend < 0.0001). No statistically significant CMS × tea, CMS × coffee, or CMS × caffeine interactions were observed.
conclusionsOur findings, based on the participants of the UK Biobank, provide little support for habitual consumption of regular coffee or tea and caffeine in improving cognitive function. On the contrary, we observed decrements in performance with intakes of these beverages which may be a result of confounding. Whether habitual caffeine intake affects cognitive function therefore remains to be tested.
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